An acute eccentric exercise increases circulating myomesin 3 fragments.

An acute eccentric exercise increases circulating myomesin 3 fragments.
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急性偏心运动会增加循环肌蛋白3片段。

DOI:
10.1186/s12576-021-00789-y
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发表时间:
2021-01-19
影响因子:
2.3
通讯作者:
Akimoto, Takayuki
Akimoto, Takayuki
中科院分区:
医学4区
文献类型:
--
作者:
Lee, Minjung;Shin, Jaehoon;Kato, Tatsuya;Kanda, Kazue;Oikawa, Satoshi;Sakuma, Jun;Sugama, Kaoru;Kawakami, Yasuo;Suzuki, Katsuhiko;Akimoto, Takayuki

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用于评估运动引起的肌肉损伤的血液生物标志物的发现吸引了许多研究人员和教练。本研究旨在确定循环肌球蛋白 3 片段的变化,作为运动引起的肌肉损伤的新型生物标志物。 9名健康男性进行10组40次重复的单腿提腿运动,负荷相当于其体重的一半。通过视觉模拟量表(VAS)评估肌肉症状。在运动前和运动后 2、4、24、48、72 和 96 小时采集血样。离心运动后 96 小时,血浆肌球蛋白 3 碎片水平显着增加。肌球蛋白 3 片段水平与肌肉损伤和肌肉症状的其他生物标志物相关。这些结果表明循环肌球蛋白 3 片段水平是反映离心运动引起的肌肉损伤的潜在生物标志物。
Discovery of blood biomarkers to evaluate exercise-induced muscle damage have attracted many researchers and coaches. This study aimed to determine changes in circulating myomesin 3 fragments as a novel biomarker for exercise-induced muscle damage. Nine healthy males performed 10 sets of 40 repetitions of one-leg calf-raise exercise by the load corresponding to the half of their body weight. Muscle symptoms were evaluated by a visual analog scale (VAS). Blood samples were collected before and 2, 4, 24, 48, 72, and 96 h post-exercise. Plasma myomesin 3 fragments levels were significantly increased at 96 h after the eccentric exercise. The myomesin 3 fragments levels were correlated with other biomarkers of muscle damage and the muscle symptoms. These results suggest that the circulating myomesin 3 fragments levels are potential biomarkers reflecting eccentric exercise-induced muscle damage.
DOI: 10.1016/j.jmb.2004.10.040
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影响因子: 5.6
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