Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes.
Acute hyperglycaemia leads to altered frontal lobe brain activity and reduced working memory in type 2 diabetes.
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DOI：
10.1371/journal.pone.0247753
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发表时间：
2021
期刊：
影响因子：
3.7
通讯作者：
Rolandsson O
中科院分区：
文献类型：
--
作者：
Backeström A;Papadopoulos K;Eriksson S;Olsson T;Andersson M;Blennow K;Zetterberg H;Nyberg L;Rolandsson O
急性高血糖如何影响2型糖尿病患者和非2型糖尿病患者的记忆功能和脑功能反应尚不清楚。我们的目的是研究急性高血糖与2型糖尿病参与者的工作记忆、语义记忆和情景记忆之间的关系，并与性别和年龄匹配的对照组进行比较。我们还评估了高血糖对工作记忆相关大脑活动的影响。共有36名2型糖尿病患者和34名对照组（平均年龄66岁）在盲法和随机顺序中接受了高血糖钳或安慰剂钳。测试了工作记忆、情景记忆和语义记忆。总体而言，考虑到安慰剂和高血糖钳，对照组的工作记忆（平均z-score 33.15±0.45）高于2型糖尿病组（平均z-score 31.8±0.44,p = 0.042）。急性高血糖对两组患者的情景记忆、语义记忆和工作记忆表现均无影响。22名参与者（10名病例，12名对照，平均年龄69岁）被随机邀请接受相同的钳夹程序来挑战工作记忆，使用1-，2-和3-back，同时通过血氧水平依赖的功能磁共振成像（fMRI）监测大脑活动。2型糖尿病患者的工作记忆在1-背部和2-背部测试中有所下降。在安慰剂钳夹期间，功能磁共振成像显示，在两组中，作为工作记忆负荷的功能，左外侧额叶皮层和前扣带皮层的BOLD信号增加（3>2>1）。在高血糖期间，对照组表现出类似的负荷依赖性fMRI反应，而2型糖尿病组的BOLD反应从2-回降至3-回。这些结果表明，大脑中葡萄糖代谢受损会影响工作记忆，可能是通过减少2型糖尿病患者重要的额叶脑区域的活动来实现的。
How acute hyperglycaemia affects memory functions and functional brain responses in individuals with and without type 2 diabetes is unclear. Our aim was to study the association between acute hyperglycaemia and working, semantic, and episodic memory in participants with type 2 diabetes compared to a sex- and age-matched control group. We also assessed the effect of hyperglycaemia on working memory–related brain activity. A total of 36 participants with type 2 diabetes and 34 controls (mean age, 66 years) underwent hyperglycaemic clamp or placebo clamp in a blinded and randomised order. Working, episodic, and semantic memory were tested. Overall, the control group had higher working memory (mean z-score 33.15 ± 0.45) than the group with type 2 diabetes (mean z-score 31.8 ± 0.44, p = 0.042) considering both the placebo and hyperglycaemic clamps. Acute hyperglycaemia did not influence episodic, semantic, or working memory performance in either group. Twenty-two of the participants (10 cases, 12 controls, mean age 69 years) were randomly invited to undergo the same clamp procedures to challenge working memory, using 1-, 2-, and 3-back, while monitoring brain activity by blood oxygen level–dependent functional magnetic resonance imaging (fMRI). The participants with type 2 diabetes had reduced working memory during the 1- and 2-back tests. fMRI during placebo clamp revealed increased BOLD signal in the left lateral frontal cortex and the anterior cingulate cortex as a function of working memory load in both groups (3>2>1). During hyperglycaemia, controls showed a similar load-dependent fMRI response, whereas the type 2 diabetes group showed decreased BOLD response from 2- to 3-back. These results suggest that impaired glucose metabolism in the brain affects working memory, possibly by reducing activity in important frontal brain areas in persons with type 2 diabetes.
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DOI：
10.1073/pnas.111134598
发表时间：
2001-06-05
影响因子：
11.1
作者：
Egan, MF;Goldberg, TE;Weinberger, DR
通讯作者：
Weinberger, DR
影响因子：
3.2
作者：
Nyberg, Lars;Andersson, Micael;Nilsson, Lars-Goran
通讯作者：
Nilsson, Lars-Goran
DOI：
10.1016/s0140-6736(17)31363-6
发表时间：
2017-12-16
期刊：
Lancet (London, England)
影响因子：
--
作者：
Livingston, Gill;Sommerlad, Andrew;Mukadam, Naaheed
通讯作者：
Mukadam, Naaheed
影响因子：
7.7
作者：
Seaquist ER;Lattemann DF;Dixon RA
通讯作者：
Dixon RA
影响因子：
4.8
作者：
Backestrom, Anna;Eriksson, Sture;Rolandsson, Olov
通讯作者：
Rolandsson, Olov