Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort.
Sex differences in foetal origins of child emotional symptoms: a test of evolutionary hypotheses in a large, general population cohort.
复制标题
DOI：
10.1111/jcpp.13229
复制
发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Hill J
中科院分区：
文献类型：
--
作者：
Braithwaite EC;Pickles A;Wright N;Sharp H;Hill J
根据威勒尔儿童健康与发展研究（WCHADS）之前的发现以及进化假设，我们对大量流行病学样本的数据进行了预先注册分析（https://osf.io/fn5g9/register/564d31db8c5e4a7c9694b2be），以测试产前母亲抑郁症状对产后母亲抑郁症状与儿童情绪问题之间关系的性别依赖性调节。雅芳父母和儿童纵向研究 (ALSPAC) 总共对 8,354 名母亲和儿童进行了从怀孕到 3.5 岁的跟踪调查。进行了产前和产后母亲抑郁症状的自我报告测量，以及儿童情绪症状的母亲报告。母亲产前和产后抑郁症与儿童性别之间存在三向交互作用（Coeff .042 95% CI 0.015 至 0.068，p = .002）。这是由产前抑郁症的缓解引起的，男孩和女孩的方向相反。在男孩中，产前抑郁症状较低后，产后抑郁症与儿童情绪症状之间的关联性较弱（交互作用项 coeff = .030，p = .001），而在女孩中，产前抑郁症状较低后，产后抑郁症与儿童情绪症状之间的关联性较强（交互项 coeff = −.012，p = .221）。我们重复了 WCHADS 的发现，即产前抑郁症以性别依赖的方式改变了产后抑郁症与儿童情绪问题之间的关联。在ALSPAC中，性别差异主要是由于男孩产前抑郁程度较低的保护作用，而在WCHADS中，性别差异的原因是女孩产前抑郁程度较低后更容易患产后抑郁。根据这些发现，在评估和实施早期干预措施时，需要考虑到与产后抑郁症相关的风险可能会因怀孕期间母亲的情绪而异，并且男孩和女孩之间也可能有所不同。
Based on previous findings from the Wirral Child Health and Development Study (WCHADS), and on evolutionary hypotheses, we preregistered analyses of data from a large epidemiological sample (https://osf.io/fn5g9/register/564d31db8c5e4a7c9694b2be), to test for sex‐dependent moderation by prenatal maternal depressive symptoms of the association between postnatal maternal depressive symptoms and child emotional problems. A total of 8,354 mothers and children were followed from pregnancy to 3.5 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). Self‐report measures of prenatal and postnatal maternal depressive symptoms, and maternal report of child emotional symptoms were administered. There was a three‐way interaction between maternal prenatal and postnatal depression, and child sex (Coeff .042 95% CI 0.015 to 0.068, p = .002). This arose from moderation by prenatal depression, in opposite directions in boys and in girls. In boys, the association between postnatal depression and child emotional symptoms was weaker following lower prenatal depressive symptoms (interaction term coeff = .030, p = .001), and in girls, to a lesser extent, the association was stronger following lower prenatal depressive symptoms (interaction term coeff = −.012, p = .221). We replicated the finding from the WCHADS that prenatal depression modifies the association between postnatal depression and children's emotional problems in a sex‐dependent fashion. In ALSPAC, the sex difference was explained mainly by a protective effect of low prenatal depression in boys, while in WCHADS, it arose from greater vulnerability of girls to postnatal depression following low prenatal depression. In the light of these findings, in evaluating and implementing early interventions, there is need to consider that risks associated with postnatal depression may vary depending on maternal mood during pregnancy and may differ between boys and girls.
登录
查看更多内容
影响因子：
3.7
作者：
Enlow, Michelle Bosquet;Sideridis, Georgios;Wright, Rosalind J.
通讯作者：
Wright, Rosalind J.
影响因子：
6.7
作者：
Sutherland S;Brunwasser SM
通讯作者：
Brunwasser SM
影响因子：
6.8
作者：
Murgatroyd C;Quinn JP;Sharp HM;Pickles A;Hill J
通讯作者：
Hill J
DOI：
10.1098/rspb.2008.0754
发表时间：
2008-11-22
影响因子：
4.7
作者：
Mathis, Alicia;Ferrari, Maud C. O.;Chivers, Douglas P.
通讯作者：
Chivers, Douglas P.
影响因子：
3.7
作者：
Braithwaite, Elizabeth C.;Murphy, Susannah E.;Hill, Jonathan
通讯作者：
Hill, Jonathan