Clustered arrangement of immunoglobulin λ constant region genes in man
Clustered arrangement of immunoglobulin λ constant region genes in man
复制标题
人类免疫球蛋白λ恒定区基因的簇排列
作者：
P. Hieter;G. Hollis;S. Korsmeyer;T. Waldmann;P. Leder
人类免疫球蛋白λ轻链位点包含6个λ样基因，它们串联在染色体DNA的一个50千碱基片段上。其中三个基因的序列对应于三种已知的非等位基因λ链同型：Mcg， Ke - Oz -和Ke - Oz+。它们围绕着一个高度多态性和明显不稳定的区域，当在大肠杆菌中克隆时，该区域被反复删除。另外三个λ样序列也被克隆出来，但尚未连接，这表明λ基因在人类基因组中形成了一个意想不到的大家族。
The immunoglobulin λ light chain locus of man contains six λ-like genes arranged tandemly on a 50-kilobase segment of chromosomal DNA. The sequences of three of these genes correspond to three known non-allelic λ chain isotypes: Mcg, Ke−Oz− and Ke−Oz+. They surround a highly polymorphic and evidently unstable region that is repeatedly deleted when cloned in Escherichia coli. Three additional, but as yet unlinked, λ-like sequences have also been cloned, suggesting that the λ genes form an unexpectedly large family within the human genome.
免疫球蛋白 lambda I 和 lambda III 恒定区基因的物理连接。
DOI：
10.1073/pnas.78.6.3829
发表时间：
1981
影响因子：
11.1
作者：
Miller,J;Bothwell,A;Storb,U
通讯作者：
Storb,U