Gait Modulation in C. elegans: An Integrated Neuromechanical Model.
Gait Modulation in C. elegans: An Integrated Neuromechanical Model.
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DOI：
10.3389/fncom.2012.00010
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发表时间：
2012
影响因子：
3.2
通讯作者：
Cohen N
中科院分区：
文献类型：
--
作者：
Boyle JH;Berri S;Cohen N
秀丽隐杆线虫拥有302个细胞的神经系统，可以在不同的环境中适应运动，表现出所谓的在液体中游泳和在致密凝胶上爬行。最近的实验表明，蠕虫在中间环境中显示出全部的中间行为。这种转变的连续性强烈表明，这些行为都源于单一潜在机制的调节。我们提出了一个C.这是一种包括神经肌肉控制系统的秀丽线虫向前运动，该神经肌肉控制系统依赖于感觉反馈机制来产生波动，并与身体和环境的物理模型相结合。我们发现，该模型再现了整个游泳爬行过渡，以及在复杂和异构的环境中的运动。除了通过对物理环境的本体感受反应之外，这是在没有调节机制的情况下实现的。操纵的模型被用来解剖建议的模式生成机制及其调制。该模型表明GABA能D类神经元在向前运动中可能发挥的作用，并进行了一些实验预测，特别是关于模型中的非线性和身体腹侧和背侧神经肌肉系统之间的对称性破坏。
Equipped with its 302-cell nervous system, the nematode Caenorhabditis elegans adapts its locomotion in different environments, exhibiting so-called swimming in liquids and crawling on dense gels. Recent experiments have demonstrated that the worm displays the full range of intermediate behaviors when placed in intermediate environments. The continuous nature of this transition strongly suggests that these behaviors all stem from modulation of a single underlying mechanism. We present a model of C. elegans forward locomotion that includes a neuromuscular control system that relies on a sensory feedback mechanism to generate undulations and is integrated with a physical model of the body and environment. We find that the model reproduces the entire swim-crawl transition, as well as locomotion in complex and heterogeneous environments. This is achieved with no modulatory mechanism, except via the proprioceptive response to the physical environment. Manipulations of the model are used to dissect the proposed pattern generation mechanism and its modulation. The model suggests a possible role for GABAergic D-class neurons in forward locomotion and makes a number of experimental predictions, in particular with respect to non-linearities in the model and to symmetry breaking between the neuromuscular systems on the ventral and dorsal sides of the body.
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影响因子：
6.1
作者：
Doll JC;Harjee N;Klejwa N;Kwon R;Coulthard SM;Petzold B;Goodman MB;Pruitt BL
通讯作者：
Pruitt BL
DOI：
10.1098/rspb.1938.0050
发表时间：
1938-10-01
期刊：
PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES
影响因子：
--
作者：
Hill, AV
通讯作者：
Hill, AV
影响因子：
10.2
作者：
LIGHTHILL, J
通讯作者：
LIGHTHILL, J
影响因子：
5.7
作者：
Harris-Warrick, Ronald M.
通讯作者：
Harris-Warrick, Ronald M.
影响因子：
1.6
作者：
Boyle, Jordan H.;Cohen, Netta
通讯作者：
Cohen, Netta