SU-8 force sensing pillar arrays for biological measurements.
SU-8 force sensing pillar arrays for biological measurements.
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DOI：
10.1039/b818622g
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发表时间：
2009-05-21
期刊：
影响因子：
6.1
通讯作者：
Pruitt BL
中科院分区：
文献类型：
--
作者：
Doll JC;Harjee N;Klejwa N;Kwon R;Coulthard SM;Petzold B;Goodman MB;Pruitt BL
机械力的产生和感觉在包括触觉在内的许多动态生物过程中起着重要作用。本文介绍了一种由多层SU-8和金属在石英衬底上构成的两轴微应变式力传感器。该传感器旨在满足测量小生物（如秀丽隐杆线虫）在运动过程中施加的触觉灵敏度和相互作用力的要求。该装置是透明的，与光学显微镜兼容，允许行为实验与定量力测量相结合。我们首次描述了野生型秀丽隐杆线虫在运动过程中探测和响应环境时产生的相互作用力的规模。该器件具有从1hz到1khz的亚μN力分辨率，> - 25 μN范围，kHz采集率和生物相容性。
The generation and sensation of mechanical force plays a role in many dynamic biological processes, including touch sensation. This paper presents a two-axis micro strain gauge force sensor constructed from multiple layers of SU-8 and metal on quartz substrates. The sensor was designed to meet requirements for measuring tactile sensitivity and interaction forces exerted during locomotion by small organisms such as the nematode Caenorhabditis elegans. The device is transparent and compatible with light microscopes, allowing behavioral experiments to be combined with quantitative force measurements. For the first time, we have characterized the scale of interaction forces generated in wild-type C. elegans in probing and responding to their environment during locomotion. The device features sub-μN force resolution from 1 Hz to 1 kHz, >25 μN range, kHz acquisition rates and biocompatibility.
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DOI：
10.1073/pnas.93.19.10417
发表时间：
1996-09-17
影响因子：
11.1
作者：
Topper, JN;Cai, JX;Gimbrone, MA
通讯作者：
Gimbrone, MA
影响因子：
4.6
作者：
Barlian, A. Alvin;Park, Sung-Jin;Pruitt, Beth L.
通讯作者：
Pruitt, Beth L.
DOI：
10.1073/pnas.94.17.9114
发表时间：
1997-08-19
影响因子：
11.1
作者：
Galbraith, CG;Sheetz, MP
通讯作者：
Sheetz, MP
DOI：
10.1073/pnas.0702138104
发表时间：
2007-10-30
影响因子：
11.1
作者：
Park, Sung-Jin;Goodman, Miriam B.;Pruitt, Beth L.
通讯作者：
Pruitt, Beth L.
影响因子：
2.7
作者：
LETOURNEAU, PC
通讯作者：
LETOURNEAU, PC