Marine lectins and their medicinal applications.
Marine lectins and their medicinal applications.
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DOI：
10.1007/s00253-015-6518-0
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发表时间：
2015-05
影响因子：
5
通讯作者：
Ng TB
中科院分区：
文献类型：
--
作者：
Cheung RC;Wong JH;Pan W;Chan YS;Yin C;Dan X;Ng TB
在过去的几十年里，海洋生物作为新的生物活性化合物的潜在来源得到了广泛的探索，对凝集素也进行了广泛的研究。来自海洋生物的凝集素在结构上是多样化的，也不同于那些从陆地生物中鉴定出来的凝集素。海洋凝集素似乎在一些生物应用中特别有用。它们诱导的免疫原性似乎可以忽略不计，因为它们相对较小，由于广泛的二硫键形成而更稳定，并且对复杂的糖偶联物和碳水化合物具有高度的特异性，而不是简单的糖。显然，与陆地上的同类相比，其中许多还没有得到广泛的研究。海洋凝集素可用于设计和开发新的潜在有用的治疗剂。本文综述了近年来海洋凝集素的分离和鉴定研究进展，这些凝集素具有潜在的药用价值。
Marine organisms have been extensively explored for the last several decades as potential sources of novel biologically active compounds, and extensive research has been conducted on lectins. Lectins derived from marine organisms are structurally diverse and also differ from those identified from terrestrial organisms. Marine lectins appear to be particularly useful in some biological applications. They seem to induce negligible immunogenicity because they have a relatively small size, are more stable due to extensive disulfide bridge formation, and have high specificity for complex glyco-conjugates and carbohydrates instead of simple sugars. It is clear that many of them have not yet been extensively studied when compared with their terrestrial counterparts. Marine lectins can be used to design and develop new potentially useful therapeutic agents. This review encompasses recent research on the isolation and identification of marine lectins with potential value in medicinal applications.
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影响因子：
5
作者：
Cheung RC;Wong JH;Pan WL;Chan YS;Yin CM;Dan XL;Wang HX;Fang EF;Lam SK;Ngai PH;Xia LX;Liu F;Ye XY;Zhang GQ;Liu QH;Sha O;Lin P;Ki C;Bekhit AA;Bekhit Ael-D;Wan DC;Ye XJ;Xia J;Ng TB
通讯作者：
Ng TB
影响因子：
4.9
作者：
Barton, Christopher;Kouokam, J. Calvin;Palmer, Kenneth E.
通讯作者：
Palmer, Kenneth E.
影响因子：
5.2
作者：
Ferir, Geoffrey;Huskens, Dana;Schols, Dominique
通讯作者：
Schols, Dominique
DOI：
10.1016/j.cbpb.2012.01.001
发表时间：
2012-04-01
影响因子：
2.2
作者：
Dresch, Roger R.;Lerner, Clea B.;Vozari-Hampe, Magdolna M.
通讯作者：
Vozari-Hampe, Magdolna M.
DOI：
10.1073/pnas.0409225102
发表时间：
2005-02-01
影响因子：
11.1
作者：
Cunha, TM;Verri, WA;Ferreira, SH
通讯作者：
Ferreira, SH