Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?
Th1 versus Th17: are T cell cytokines relevant in multiple sclerosis?
复制标题
TH1对TH17：T细胞细胞因子在多发性硬化症中是否相关？
DOI：
10.1016/j.bbadis.2010.05.012
复制
发表时间：
2011-02
影响因子：
6.2
通讯作者：
Racke, Michael K.
中科院分区：
文献类型：
--
作者：
Lovett-Racke, Amy E.;Yang, Yuhong;Racke, Michael K.
在过去的二十年中，随着免疫学和神经生物学领域为探索多发性硬化症的病因和机制提供了新的途径，我们对多发性硬化症（MS）病理生理学的理解有了显著的发展。几十年来，人们已经知道T细胞具有不同的细胞因子表型，但MS中致病性T细胞的细胞因子表型仍然是一个有争议的领域。在EAE中，分别由Th1和Th17细胞产生的IFNγ和IL-17似乎不是决定T细胞致脑性的关键因素。然而，IL-23、T-bet和STAT4等分子似乎是至关重要的，但尚不清楚所有这些分子是否都参与了一个共同的、尚未定义的途径，还是以协同方式起作用，最终导致脑致生性，仍有待确定。因此，MS中效应T细胞的研究重点应该集中在定义Th1和Th17细胞的细胞因子的上游途径上，因为下游产物，如IFNγ和IL-17，可能不是效应T细胞是否能够运输到中枢神经系统并诱导炎症脱髓鞘的关键决定因素。
Our understanding of the pathophysiology of multiple sclerosis (MS) has evolved significantly over the past two decades as the fields of immunology and neurobiology provide new avenues of exploration into the cause and mechanism of the disease. It has been known for decades that T cells have different cytokine phenotypes, yet the cytokine phenotype of pathogenic T cells in MS is still an area of debate. In EAE, it appears that IFNγ and IL-17, produced by Th1 and Th17 cells respectively, are not the critical factor that determines T cell encephalitogenicity. However, there are molecules such as IL-23, T-bet and STAT4, that appear to be critical, yet it is unclear whether all these molecules contribute to a common, yet undefined pathway, or act in a synergistic manner which culminates in encephalitogenicity has still to be determined. Therefore, the focus of research on effector T cells in MS should focus on pathways upstream of the cytokines that define Th1 and Th17 cells, since downstream products, such as IFNγ and IL-17, probably are not critical determinants of whether an effector T cells is capable of trafficking to the CNS and inducing inflammatory demyelination.
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T-BET的丧失，但不是STAT1阻止了实验性自身免疫性脑脊髓炎的发展。
影响因子：
15.3
作者：
Bettelli, E;Sullivan, B;Szabo, SJ;Sobel, RA;Glimcher, H;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
3.3
作者：
Elhofy A;Depaolo RW;Lira SA;Lukacs NW;Karpus WJ
通讯作者：
Karpus WJ
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
影响因子：
15.9
作者：
Haak, Stefan;Croxford, Andrew L.;Waisman, Ari
通讯作者：
Waisman, Ari
影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.