Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis.
Lipopolysaccharide and soluble CD14 in cord blood plasma are associated with prematurity and chorioamnionitis.
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DOI：
10.1038/pr.2013.182
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发表时间：
2014-01
影响因子：
3.6
通讯作者：
Luciano, Angel A.
中科院分区：
文献类型：
--
作者：
Martinez-Lopez, Denise G.;Funderburg, Nicholas T.;Cerissi, Adam;Rifaie, Reema;Aviles-Medina, Laura;Llorens-Bonilla, Braulio J.;Sleasman, John;Luciano, Angel A.
脂多糖（LPS）是革兰氏阴性菌的一种内毒素，可导致动物早产，并被认为是引发人类早产和全身并发症的一个因素。关于足月和早产儿脐带血（CB）中的LPS及其与母体和胎儿特征的关系，我们所知甚少。CB来自分娩后的足月婴儿（n=15）和早产儿（n=76）。血浆LPS、c反应蛋白（CRP）和可溶性CD14 （sCD14）水平采用市售试剂盒（鲎试剂（LAL）测定和ELISA）测定。建立了四个线性回归模型，以确定预测血浆LPS水平的独立变量。早产儿的CB LPS （24.48 vs. 1 pg/ml）、CRP （87.9 vs. 47 ng/ml）和sCD14 （0.32 vs.0.35µg/ml）水平显著高于足月婴儿。CB LPS水平与胎龄、出生体重、CRP水平、sCD14水平以及临床和组织学绒毛膜羊膜炎的存在相关。我们的数据表明LPS与早产和炎症（CRP升高和绒毛膜羊膜炎）有关。这些发现可能与了解LPS在早产中的作用及其在早产儿发病率中的可能作用有关。
Lipopolysaccharide (LPS), an endotoxin of gram-negative bacteria, causes preterm birth in animals and has been implicated as a factor triggering preterm labor and systemic complications in humans. Little is known regarding LPS in the cord blood (CB) of term and preterm infants and its association with maternal and fetal characteristics. CB was obtained from term (n=15) and preterm infants (n=76) after delivery. Plasma levels of LPS, C-Reactive Protein (CRP) and soluble CD14 (sCD14) were measured using commercially available kits (Limulus Amebocyte Lysate (LAL) assay and ELISA). Four linear regression models were created in order to identify independent variables that predict plasma LPS levels. CB LPS (24.48 vs. 1 pg/ml), CRP (87.9 vs. 47 ng/ml) and sCD14 (0.32 vs.0.35 µg/ml) levels were significantly higher in the preterm than the term infants. CB LPS levels correlate with gestational age, birth weight, CRP levels, sCD14 levels and the presence of both clinical and histological chorioamnionitis. Our data suggest that LPS is associated with preterm labor and inflammation (CRP elevation and chorioamnionitis). These findings may be relevant to understand the role of LPS in prematurity and its possible role in preterm morbidities.
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DOI：
10.1097/mpg.0b013e31818936b8
发表时间：
2009-03-01
影响因子：
2.9
作者：
Giannone, Peter J.;Nankervis, Tcraio A.;Reber, Kristina M.
通讯作者：
Reber, Kristina M.
DOI：
10.1080/713605697
发表时间：
2002-11-01
期刊：
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians
影响因子：
--
作者：
Espinoza, J;Chaiworapongsa, T;Yoon, B H
通讯作者：
Yoon, B H
DOI：
10.1152/ajplung.90405.2008
发表时间：
2009-05-01
影响因子：
4.9
作者：
Cao, Lei;Wang, Jinxia;Post, Martin
通讯作者：
Post, Martin
影响因子：
4.4
作者：
Leaphart, Cynthia L.;Cavallo, Jaime;Hackam, David J.
通讯作者：
Hackam, David J.
影响因子：
3.7
作者：
Luciano AA;Yu H;Jackson LW;Wolfe LA;Bernstein HB
通讯作者：
Bernstein HB