Preterm labor and chorioamnionitis are associated with neonatal T cell activation.
Preterm labor and chorioamnionitis are associated with neonatal T cell activation.
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DOI：
10.1371/journal.pone.0016698
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发表时间：
2011-02-08
期刊：
影响因子：
3.7
通讯作者：
Bernstein HB
中科院分区：
文献类型：
--
作者：
Luciano AA;Yu H;Jackson LW;Wolfe LA;Bernstein HB
早产的特征是先天免疫激活和促炎细胞因子水平升高。这种良好的相关性使我们假设早产也与新生儿T淋巴细胞活化和成熟有关。在足月、早产和分娩并发临床绒毛膜炎后采集脐带血样本。通过流式细胞术分析定量活化标志物表达。早产后出生的婴儿表现出增强的CD 4 + T淋巴细胞活化，如通过CD 25（足月9.72% vs.早产17.67%，p = 0.0001）、HLA-DR（足月0.91% vs.早产1.92%，p = 0.0012）和CD 69表达（足月0.38% vs.早产1.20%，p = 0.0003）确定的。 临床绒毛膜炎后分娩的新生儿也表现出T细胞活化增加。早产儿CD 45 RO + T细胞的频率增加。早产与新生儿CD 4 + T细胞活化和CD 45 RO + T细胞频率增加有关。这些发现支持了胎儿适应性免疫系统在子宫内的激活与早产密切相关的概念。
Preterm parturition is characterized by innate immune activation and increased proinflammatory cytokine levels. This well established association leads us to hypothesize that preterm delivery is also associated with neonatal T lymphocyte activation and maturation. Cord blood samples were obtained following term, preterm, and deliveries complicated by clinical chorioamnionitis. Activation marker expression was quantitated by flow cytometric analysis. Infants born following preterm delivery demonstrated enhanced CD4+ T lymphocyte activation, as determined by CD25 (Term 9.72% vs. Preterm 17.67%, p = 0.0001), HLA-DR (Term 0.91% vs. Preterm 1.92%, p = 0.0012), and CD69 expression (Term 0.38% vs. Preterm 1.20%, p = 0.0003). Neonates delivered following clinical chorioamnionitis also demonstrated increased T cell activation. Preterm neonates had an increased frequency of CD45RO+ T cells. Preterm parturition is associated with neonatal CD4+ T cell activation, and an increased frequency of CD45RO+ T cells. These findings support the concept that activation of the fetal adaptive immune system in utero is closely associated with preterm labor.
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影响因子：
2.6
作者：
Matsuda, Yoshio;Kato, Hidehito;Uchiyama, Takehiko
通讯作者：
Uchiyama, Takehiko
影响因子：
158.5
作者：
MCCORMICK, MC
通讯作者：
MCCORMICK, MC
影响因子：
1.8
作者：
Esplin, MS;Romero, R;Adashi, EY
通讯作者：
Adashi, EY
DOI：
10.1016/s0002-9378(00)70502-3
发表时间：
2000-01-01
影响因子：
9.8
作者：
Athayde, N;Romero, R;Edwin, SS
通讯作者：
Edwin, SS
DOI：
10.1111/j.1600-0897.1994.tb01101.x
发表时间：
1994-09-01
影响因子：
3.6
作者：
ROMERO, R;GOMEZ, R;COTON, DB
通讯作者：
COTON, DB