Quality over quantity: optimizing co-translational protein folding with non-'optimal' synonymous codons.
Quality over quantity: optimizing co-translational protein folding with non-'optimal' synonymous codons.
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DOI：
10.1016/j.sbi.2016.06.002
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发表时间：
2016-06
影响因子：
6.8
通讯作者：
Clark, Patricia L.
中科院分区：
文献类型：
--
作者：
Jacobson, Giselle N.;Clark, Patricia L.
蛋白质折叠发生在类似于核糖体形成肽键的时间尺度上，这长期以来引发了人们的猜测，即改变翻译速率可能会改变体内蛋白质的折叠机制甚至最终折叠结构。最近的研究结果为这一模型提供了强有力的支持：同义替换为具有不同使用频率的密码子，这些密码子通常以不同的速率翻译，已被证明可以显着改变某些蛋白质的共翻译折叠机制，从而改变细胞功能。本文就同义密码子使用、翻译速率和共翻译蛋白质折叠机制之间的关系作一综述。
Protein folding occurs on a time scale similar to peptide bond formation by the ribosome, which has long sparked speculation that altering translation rate could alter the folding mechanism or even the final folded structure of a protein in vivo. Recent results have provided strong support for this model: synonymous substitutions to codons with different usage frequency, which are often translated at different rates, have been shown to significantly alter the co-translational folding mechanism of some proteins, leading to altered cell function. Here we review recent progress towards understanding the connections between synonymous codon usage, translation rate and co-translational protein folding mechanisms.
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