Stem-like T cells and niches: Implications in human health and disease.
Stem-like T cells and niches: Implications in human health and disease.
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干细胞样 T 细胞和生态位：对人类健康和疾病的影响
DOI：
10.3389/fimmu.2022.907172
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发表时间：
2022
影响因子：
7.3
通讯作者：
Yang, Li
中科院分区：
文献类型：
--
作者：
Yi, Linglu;Yang, Li
最近，越来越多的证据阐明了具有干细胞样特征的T细胞在长期维持T细胞应答和免疫治疗后更好的患者结局中的重要作用。TSL细胞的命运与许多生理和病理人类过程相关。在这篇综述中，我们描述了目前的进展，证明干细胞样T（TSL）细胞是人类健康和疾病的核心球员。对TSL细胞的进化特征、机制和功能进行了阐述。此外，我们还讨论了不同的小生境的进口作用，以及它们如何影响TSL细胞的干细胞。此外，我们还概述了目前可用的策略，以产生TSL细胞和相关的影响因素。此外，我们总结了TSL细胞在两个领域的治疗意义：疫苗，ICB和过继性T细胞治疗的干细胞增强，以及自身免疫性疾病的干细胞破坏。
Recently, accumulating evidence has elucidated the important role of T cells with stem-like characteristics in long-term maintenance of T cell responses and better patient outcomes after immunotherapy. The fate of TSL cells has been correlated with many physiological and pathological human processes. In this review, we described present advances demonstrating that stem-like T (TSL) cells are central players in human health and disease. We interpreted the evolutionary characteristics, mechanism and functions of TSL cells. Moreover, we discuss the import role of distinct niches and how they affect the stemness of TSL cells. Furthermore, we also outlined currently available strategies to generate TSL cells and associated affecting factors. Moreover, we summarized implication of TSL cells in therapies in two areas: stemness enhancement for vaccines, ICB, and adoptive T cell therapies, and stemness disruption for autoimmune disorders.
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