Imaging genetics paradigms in depression research: Systematic review and meta-analysis.
Imaging genetics paradigms in depression research: Systematic review and meta-analysis.
复制标题
DOI：
10.1016/j.pnpbp.2018.05.012
复制
发表时间：
2018-08-30
影响因子：
5.6
通讯作者：
Carvalho AF
中科院分区：
文献类型：
--
作者：
Pereira LP;Köhler CA;Stubbs B;Miskowiak KW;Morris G;de Freitas BP;Thompson T;Fernandes BS;Brunoni AR;Maes M;Pizzagalli DA;Carvalho AF
涉及重度抑郁症（MDD）参与者的成像遗传学研究已经扩大。然而，调查结果并不一致。因此，我们对截至2017年6月30日在主要数据库中招募MDD参与者的成像遗传学研究进行了系统性综述和荟萃分析。65项研究符合合格标准（N=4034例MDD参与者和3293例对照），纳入研究的方法学质量存在显著的研究间变异性。然而，该文献中几乎没有重复的发现，只有22项研究提供了荟萃分析的数据（882例MDD受试者和616例对照）。与非携带者相比，携带BDNF Val 66 Met“Met”（386名MDD参与者和376名对照）或5-HTTLPR短“S”（310名MDD参与者和230名对照）风险等位基因的MDD参与者或对照组的海马总体积没有显著差异。通过荟萃回归和亚组分析探讨了研究间的异质性。性别分布、药物的使用、用于测量海马的分割方法和年龄成为评估5-HTTLPR短S等位基因和海马体积相关性的研究中异质性的潜在来源。我们的数据还表明，纳入研究的方法学质量，发表年份，以及纳入脑体积作为协变量，有助于评估BDNF Val 66 Met 'Met'风险等位基因和海马体积相关性的研究的异质性。在探索性体素荟萃分析中，携带5-HTTLPR短“S”等位基因的MDD参与者主要在胼胝体中存在白色物质微结构异常，而BDNF Val 66 Met“Met”等位基因的携带者与非携带者相比具有更大的灰质体积和右额中回的过度激活。总之，包括MDD参与者的成像遗传学研究中出现了很少的重复发现。然而，我们探索并确定了不同研究中异质性的具体来源，这可以为增强这一新兴领域的可重复性提供见解。
Imaging genetics studies involving participants with major depressive disorder (MDD) have expanded. Nevertheless, findings have been inconsistent. Thus, we conducted a systematic review and meta-analysis of imaging genetics studies that enrolled MDD participants across major databases through June 30th, 2017. Sixty-five studies met eligibility criteria (N=4034 MDD participants and 3293 controls), and there was substantial between-study variability in the methodological quality of included studies. However, few replicated findings emerged from this literature with only 22 studies providing data for meta-analyses (882 participants with MDD and 616 controls). Total hippocampal volumes did not significantly vary in MDD participants or controls carrying either the BDNF Val66Met ‘Met’ (386 participants with MDD and 376 controls) or the 5-HTTLPR short ‘S’ (310 participants with MDD and 230 controls) risk alleles compared to non-carriers. Heterogeneity across studies was explored through meta-regression and subgroup analyses. Gender distribution, the use of medications, segmentation methods used to measure the hippocampus, and age emerged as potential sources of heterogeneity across studies that assessed the association of 5-HTTLPR short ‘S’ alleles and hippocampal volumes. Our data also suggest that the methodological quality of included studies, publication year, and the inclusion of brain volume as a covariate contributed to the heterogeneity of studies that assessed the association of the BDNF Val66Met ‘Met’ risk allele and hippocampal volumes. In exploratory voxel-wise meta-analyses, MDD participants carrying the 5-HTTLPR short ‘S’ allele had white matter microstructural abnormalities predominantly in the corpus callosum, while carriers of the BDNF Val66Met ‘Met’ allele had larger grey matter volumes and hyperactivation of the right middle frontal gyrus compared to non-carriers. In conclusion, few replicated findings emerged from imaging genetics studies that included participants with MDD. Nevertheless, we explored and identified specific sources of heterogeneity across studies, which could provide insights to enhance the reproducibility of this emerging field.
登录
查看更多内容
影响因子：
10.6
作者：
Bogdan R;Salmeron BJ;Carey CE;Agrawal A;Calhoun VD;Garavan H;Hariri AR;Heinz A;Hill MN;Holmes A;Kalin NH;Goldman D
通讯作者：
Goldman D
影响因子：
6.6
作者：
Alexopoulos, George S.;Murphy, Christopher F.;Gunning-Dixon, Faith M.;Glatt, Charles E.;Latoussakis, Vassilios;Kelly, Robert E., Jr.;Kanellopoulos, Dora;Klimstra, Sibel;Lim, Kelvin O.;Young, Robert C.;Hoptman, Matthew J.
通讯作者：
Hoptman, Matthew J.
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N
影响因子：
4.7
作者：
Bartzokis G
通讯作者：
Bartzokis G
DOI：
10.1111/j.1601-183x.2011.00714.x
发表时间：
2011-10
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Cole J;Weinberger DR;Mattay VS;Cheng X;Toga AW;Thompson PM;Powell-Smith G;Cohen-Woods S;Simmons A;McGuffin P;Fu CH
通讯作者：
Fu CH