Impact of hepatitis B virus infection on hepatic metabolic signaling pathway.
Impact of hepatitis B virus infection on hepatic metabolic signaling pathway.
复制标题
乙型肝炎病毒感染对肝脏代谢信号通路的影响。
DOI：
10.3748/wjg.v22.i36.8161
复制
发表时间：
2016-09-28
影响因子：
4.3
通讯作者：
Yang ZG
中科院分区：
文献类型：
--
作者：
Shi YX;Huang CJ;Yang ZG
越来越多的流行病学研究表明，B型肝炎病毒（HBV）感染者存在代谢紊乱，提示HBV感染与宿主代谢存在临床相关性。为了更深入地了解HBV和肝脏代谢之间复杂的相互作用，我们系统地回顾了HBV感染引起的不同代谢信号通路的这些改变。HBV感染可干扰肝脏糖、脂、核酸、胆汁酸、维生素等代谢。葡萄糖和脂质代谢是一个特别关注的问题，因为HBV显著促进了肝细胞生成、葡萄糖有氧氧化、戊糖磷酸途径、脂肪酸合成或氧化、磷脂和胆固醇生物合成。这些改变的代谢途径不仅参与B型肝炎的病理过程，而且参与代谢紊乱，增加并发症的发生，如肝细胞癌和肝脂肪变性。因此，更清楚地了解受HBV影响的肝脏代谢途径及其发病机制是必要的，以开发更多的新的治疗策略，靶向病毒根除。
A growing body of epidemiologic research has demonstrated that metabolic derangement exists in patients with hepatitis B virus (HBV) infection, indicating that there are clinical associations between HBV infection and host metabolism. In order to understand the complex interplay between HBV and hepatic metabolism in greater depth, we systematically reviewed these alterations in different metabolic signaling pathways due to HBV infection. HBV infection interfered with most aspects of hepatic metabolic responses, including glucose, lipid, nucleic acid, bile acid and vitamin metabolism. Glucose and lipid metabolism is a particular focus due to the significant promotion of gluconeogenesis, glucose aerobic oxidation, the pentose phosphate pathway, fatty acid synthesis or oxidation, phospholipid and cholesterol biosynthesis affected by HBV. These altered metabolic pathways are involved in the pathological process of not only hepatitis B, but also metabolic disorders, increasing the occurrence of complications, such as hepatocellular carcinoma and liver steatosis. Thus, a clearer understanding of the hepatic metabolic pathways affected by HBV and its pathogenesis is necessary to develop more novel therapeutic strategies targeting viral eradication.
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DOI：
10.1073/pnas.0404297101
发表时间：
2004-08-03
影响因子：
11.1
作者：
Chen, GX;Liang, GS;Brown, MS
通讯作者：
Brown, MS
影响因子：
4.1
作者：
Kim, KyeongJin;Kim, Kook Hwan;Cheong, JaeHun
通讯作者：
Cheong, JaeHun
DOI：
10.1073/pnas.79.6.1698
发表时间：
1982-01-01
期刊：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES
影响因子：
--
作者：
ESKO, JD;NISHIJIMA, M;RAETZ, CRH
通讯作者：
RAETZ, CRH
DOI：
10.1073/pnas.89.19.9059
发表时间：
1992-10-01
影响因子：
11.1
作者：
HUAN, BF;SIDDIQUI, A
通讯作者：
SIDDIQUI, A
乙型肝炎病毒通过 HBx 介导的 Nrf2 激活刺激 G6PD 表达
影响因子：
9
作者：
Liu B;Fang M;He Z;Cui D;Jia S;Lin X;Xu X;Zhou T;Liu W
通讯作者：
Liu W