Monitoring LITT thermal penetration depth using real-time analysis of backscattered light.
Monitoring LITT thermal penetration depth using real-time analysis of backscattered light.
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DOI：
10.1002/jbio.201200082
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发表时间：
2014-06
影响因子：
2.8
通讯作者：
Gannot I
中科院分区：
文献类型：
--
作者：
Shacham R;Steinberg I;Gandjbakhche AH;Gannot I
实时监测热穿透深度（TPD）在各种临床程序中是必不可少的，例如激光间质热治疗（LITT）。MRI通常用于此目的，尽管体积庞大且昂贵。在本文中，我们提出了一种替代的新方法的光学反馈系统的基础上的漫反射治疗过程中从组织的变化。采用蒙特-卡罗模拟方法推导了背散射方向图与TPD的关系。几种方法的图像分析开发的TPD估计。每个产生一组线性依赖于TPD的参数。为了在实验上测试这些，在多个波长下处理期间在体外监测组织样品。采用信噪比和决定系数对各种方法和波长进行比较，确定最佳方法。这样的系统和算法可以用于在激光热疗和其他临床程序期间的实时体内控制。对组织样本进行设置（右）和图像分析（左），以估计热穿透深度（TPD）。
Real-time monitoring of the thermal penetration depth (TPD) is essential in various clinical procedures, such as Laser Interstitial Thermal Therapy (LITT). MRI is commonly used to this end, though bulky and expensive. In this paper, we present an alternative novel method for an optical feedback system based on changes in the diffused reflection from the tissue during treatment. Monte-Carlo simulation was used to deduce the relations between the backscattered pattern and the TPD. Several methods of image analysis are developed for TPD estimation. Each yields a set of parameters which are linearly dependent on the TPD. In order to test these experimentally, tissue samples were monitored in-vitro during treatment at multiple wavelengths. The SNR and coefficient of determination were used to compare the various methods and wavelengths and to deter-mine the preferred method. Such system and algorithms may be used for real-time in-vivo control during laser thermotherapy and other clinical procedures. Setup (right) and image analysis (left) preformed on tissue sample for estimation of the Thermal Penetration Depth (TPD).
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