Biologically optimized nanosized molecules and particles: more than just size.
Biologically optimized nanosized molecules and particles: more than just size.
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DOI：
10.1021/bc200111p
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发表时间：
2011-06-15
影响因子：
4.7
通讯作者：
Kobayashi, Hisataka
中科院分区：
文献类型：
--
作者：
Longmire, Michelle R.;Ogawa, Mikako;Choyke, Peter L.;Kobayashi, Hisataka
纳米材料在生物和医学上的广泛应用，使得更好地了解体内粒子的化学和物理决定因素成为一个重要问题。纳米技术使我们能够设计出大量具有不同化学和生物特性的分子，每个分子都有特定的大小、电荷、亲水性、形状和灵活性。迄今为止，许多研究都集中在颗粒大小作为生物分布和清除的决定因素的作用上。此外，我们所知道的纳米颗粒特性和药代动力学之间的关系的大部分研究都局限于总平均流体动力学大小。然而，粒子形状和柔韧性等其他特征影响着体内行为，这对于设计和合成纳米分子变得越来越重要。在这里，我们讨论了作为显像剂的纳米分子在体内行为的决定因素，重点是树突基造影剂。我们的目标是讨论经常被忽视或尚未被考虑的影响合成纳米分子在体内行为的因素，并旨在突出当前理解中的重要空白。
The expanded biological and medical applications of nanomaterials, place a premium on the better understanding the chemical and physical determinants of in vivo particles. Nanotechnology allows us to design a vast array of molecules with distinct chemical and biological characteristics, each with a specific size, charge, hydrophilicity, shape, and flexibility. To date, much research has focused on the role of particle size as a determinant of biodistribution and clearance. Additionally, much of what we know about the relationship between nanoparticle traits and pharmacokinetics has involved research limited to the gross average hydrodynamic size. Yet, other features such as particle shape and flexibility affect in vivo behavior and become increasingly important for designing and synthesizing nano-sized molecules. Herein, we discuss determinants of in vivo behavior of nano-sized molecules used as imaging agents with a focus on dendrimer-based contrast agents. We aim to discuss often overlooked or, yet to be considered, factors that affect in vivo behavior of synthetic nano-sized molecules as well as aim to highlight important gaps in current understanding.
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