Deferoxamine reverses radiation induced hypovascularity during bone regeneration and repair in the murine mandible.
Deferoxamine reverses radiation induced hypovascularity during bone regeneration and repair in the murine mandible.
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DOI：
10.1016/j.bone.2012.01.019
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发表时间：
2012-05
期刊：
影响因子：
4.1
通讯作者：
Buchman, Steven R.
中科院分区：
文献类型：
--
作者：
Farberg, Aaron S.;Jing, Xi L.;Monson, Laura A.;Donneys, Alexis;Tchanque-Fossuo, Catherine N.;Deshpande, Sagar S.;Buchman, Steven R.
关键词：
去铁胺 (DFO) 是一种铁螯合剂，也被证明可以增加血管生成。我们假设 DFO 的血管生成特性将通过恢复牵张部位周围的血管分布来改善 X 射线放射治疗 (XRT) 后牵张成骨 (DO) 中的骨再生。三组 Sprague-Dawley 大鼠的左下颌骨受到牵拉。两组接受术前分割 XRT，其中一组在注意力分散期间接受 DFO 治疗。巩固后，对动物进行灌注并用 microCT 成像以计算血管放射形态学。辐射导致分散再生的血管指标严重下降，从而导致临床结果不佳。 DFO 治疗组显示 DO 骨再生得到改善，血管显着恢复和增殖。这组实验定量证明了 DFO 能够缓和 XRT 在下颌 DO 中的抗血管生成作用。这些令人兴奋的结果表明，DFO 可能是一种可行的治疗选择，旨在减轻 XRT 对新骨形成的破坏性影响。
Deferoxamine (DFO) is an iron-chelating agent that has also been shown to increase angiogenesis. We hypothesize that the angiogenic properties of DFO will improve bone regeneration in distraction osteogenesis (DO) after x-ray radiation therapy (XRT) by restoring the vascularity around the distraction site. Three groups of Sprague-Dawley rats underwent distraction of the left mandible. Two groups received pre-operative fractionated XRT, and one of these groups was treated with DFO during distraction. After consolidation, the animals were perfused and imaged with microCT to calculate vascular radiomorphometrics. Radiation inflicted a severe diminution in the vascular metrics of the distracted regenerate and consequently led to poor clinical outcome. The DFO treated group revealed improved DO bone regeneration with a substantial restoration and proliferation of vascularity. This set of experiments quantitatively demonstrates the ability of DFO to temper the anti-angiogenic effect of XRT in mandibular DO. These exciting results suggest that DFO may be a viable treatment option aimed at mitigating the damaging effects of XRT on new bone formation.
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影响因子：
3.6
作者：
Dudziak, ME;Saadeh, PB;Longaker, MT
通讯作者：
Longaker, MT
影响因子：
1.5
作者：
Rowe, NM;Mehrara, BJ;Longaker, MT
通讯作者：
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脯氨酰羟化酶抑制剂可增加小鼠股骨骨折后的新血管生成和愈伤组织形成。
影响因子：
2.8
作者：
Shen, Xing;Wan, Chao;Ramaswamy, Girish;Mavalli, Mahendra;Wang, Ying;Duvall, Craig L.;Deng, Lian Fu;Guldberg, Robert E.;Eberhart, Alan;Clemens, Thomas L.;Gilbert, Shawn R.
通讯作者：
Gilbert, Shawn R.
影响因子：
3.6
作者：
HIDALGO, DA
通讯作者：
HIDALGO, DA
影响因子：
6.2
作者：
Fang, TD;Salim, A;Longaker, MT
通讯作者：
Longaker, MT