Survival of human coronaviruses 229E and OC43 in suspension and after drying onsurfaces: a possible source ofhospital-acquired infections.
Survival of human coronaviruses 229E and OC43 in suspension and after drying onsurfaces: a possible source ofhospital-acquired infections.
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DOI：
10.1053/jhin.2000.0795
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发表时间：
2000-09
期刊：
影响因子：
--
通讯作者：
Talbot PJ
中科院分区：
文献类型：
--
作者：
Sizun J;Yu MW;Talbot PJ
人类冠状病毒（HCoV）的OC 43和229 E株引起三分之一的普通感冒，并在早产儿中报告了医院获得性上呼吸道HCoV感染。为了评估可能的感染源，研究了水性悬浮液中以及代表医院环境的吸收性和非吸收性表面上的病毒存活。还表征了病毒对标准产品化学消毒的敏感性。病毒在盐溶液中存活长达六天，但在培养基中存活较少，有或没有添加细胞。干燥后，HCoV-229 E在各种表面（铝、无菌乳胶外科手套、无菌海绵）上3小时后仍可检测到感染性，但HCoV-OC 43存活1小时或更短。在测试的各种化学消毒剂中，Proviodine®将病毒感染滴度降低至少50%。这项研究表明，表面和悬浮液可以被认为是可能的污染源，可能导致医院获得性感染HCoV，并应适当消毒。
Strains OC43 and 229E of human coronaviruses (HCoV) cause one-third of common colds and hospital-acquired upper respiratory tract HCoV infections have been reported in premature newborns. To evaluate possible sources of infection, virus survival was studied in aqueous suspensions and on absorptive and non-absorptive surfaces representative of a hospital environment. Virus susceptibility to chemical disinfection with standard products was also characterized. Virus survived in saline solution for as long as six days but less in culture medium, with or without added cells. After drying, HCoV-229E infectivity was still detectable after 3h on various surfaces (aluminum, sterile latex surgical gloves, sterile sponges) but HCoV-OC43 survived 1h or less. Of the various chemical disinfectants tested, Proviodine® reduced the virus infectious titre by at least 50%. This study suggests that surfaces and suspensions can be considered as possible sources of contamination that may lead to hospital-acquired infections with HCoV and should be appropriately disinfected.
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影响因子：
3.8
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