PGE(2) suppression of innate immunity during mucosal bacterial infection.
PGE(2) suppression of innate immunity during mucosal bacterial infection.
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PGE（2）在粘膜细菌感染期间抑制先天免疫。
DOI：
10.3389/fcimb.2013.00045
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发表时间：
2013
影响因子：
5.7
通讯作者：
Morici LA
中科院分区：
文献类型：
--
作者：
Agard M;Asakrah S;Morici LA
前列腺素E2（PGE 2）是一种重要的脂质介质，在急性和慢性感染的炎症和免疫反应。在各种促炎刺激物如脂多糖（LPS）、白细胞介素（IL）-1β和肿瘤坏死因子（TNF）-α刺激下，PGE 2合成通过环加氧酶的表达上调。具有生物活性的PGE 2能够通过四种主要受体发出信号以引起反应。PGE 2是调节几种免疫细胞的活化、成熟、迁移和细胞因子分泌的关键分子，特别是参与先天免疫的那些，如巨噬细胞、嗜中性粒细胞、自然杀伤细胞和树突细胞。革兰氏阴性菌和革兰氏阳性菌均可诱导PGE 2的合成，以调节细菌致病过程中的免疫反应。本文将重点介绍PGE 2在先天免疫中的作用以及细菌性病原体如何影响肠道和肺部感染时PGE 2的产生。许多细菌病原体在感染期间促进PGE 2应答的保守能力表明阻止保护性促炎免疫应答的共同信号传导机制。在感染期间抑制PGE 2产生和信号传导可能代表治疗细菌感染的治疗替代方案。进一步研究PGE 2对先天免疫的免疫抑制作用将有助于更好地了解PGE 2途径中的潜在治疗靶点。
Prostaglandin E2 (PGE2) is an important lipid mediator in inflammatory and immune responses during acute and chronic infections. Upon stimulation by various proinflammatory stimuli such as lipopolysaccharide (LPS), interleukin (IL)-1β, and tumor necrosis factor (TNF)-α, PGE2 synthesis is upregulated by the expression of cyclooxygenases. Biologically active PGE2 is then able to signal through four primary receptors to elicit a response. PGE2 is a critical molecule that regulates the activation, maturation, migration, and cytokine secretion of several immune cells, particularly those involved in innate immunity such as macrophages, neutrophils, natural killer cells, and dendritic cells. Both Gram-negative and Gram-positive bacteria can induce PGE2 synthesis to regulate immune responses during bacterial pathogenesis. This review will focus on PGE2 in innate immunity and how bacterial pathogens influence PGE2 production during enteric and pulmonary infections. The conserved ability of many bacterial pathogens to promote PGE2 responses during infection suggests a common signaling mechanism to deter protective pro-inflammatory immune responses. Inhibition of PGE2 production and signaling during infection may represent a therapeutic alternative to treat bacterial infections. Further study of the immunosuppressive effects of PGE2 on innate immunity will lead to a better understanding of potential therapeutic targets within the PGE2 pathway.
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影响因子：
6.7
作者：
Alba-Loureiro, TC;Martins, EF;Sannomiya, P
通讯作者：
Sannomiya, P
影响因子：
5.8
作者：
Burelout, Chantal;Thibault, Nathalie;Bourgoin, Sylvain G.
通讯作者：
Bourgoin, Sylvain G.
影响因子：
4.6
作者：
Aronoff DM
通讯作者：
Aronoff DM
DOI：
10.1084/jem.20080767
发表时间：
2008-11-24
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chen M;Divangahi M;Gan H;Shin DS;Hong S;Lee DM;Serhan CN;Behar SM;Remold HG
通讯作者：
Remold HG
影响因子：
4.8
作者：
Ejima, K;Layne, MD;Perrella, MA
通讯作者：
Perrella, MA