Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
Robust SARS-CoV-2-specific T cell immunity is maintained at 6 months following primary infection.
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DOI：
10.1038/s41590-021-00902-8
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发表时间：
2021-05
影响因子：
30.5
通讯作者：
Moss P
中科院分区：
文献类型：
--
作者：
Zuo J;Dowell AC;Pearce H;Verma K;Long HM;Begum J;Aiano F;Amin-Chowdhury Z;Hoschler K;Brooks T;Taylor S;Hewson J;Hallis B;Stapley L;Borrow R;Linley E;Ahmad S;Parker B;Horsley A;Amirthalingam G;Brown K;Ramsay ME;Ladhani S;Moss P
针对 SARS-CoV-2 的免疫反应对于控制疾病至关重要，但人们担心免疫力减弱可能会导致再次感染。我们分析了 100 名捐赠者在感染后 6 个月内 SARS-CoV-2 特异性 T 细胞反应的程度和表型。通过 ELISPOT 和/或 ICS 分析，所有供体中都存在 T 细胞反应，其特征是 CD4+ T 细胞反应占主导地位，并具有强 IL-2 细胞因子表达。经历过有症状感染的捐赠者的 T 细胞反应中位数要高出 50%，这表明原发感染的严重程度为细胞免疫建立了一个“设定点”。 T 细胞对刺突蛋白和核蛋白/膜蛋白的反应与峰值抗体水平相关。此外，较高水平的核蛋白特异性 T 细胞与 NP 特异性抗体水平的保留相关，尽管与尖峰特异性反应没有观察到这种相关性。总之，我们的数据令人放心，功能性 SARS-CoV-2 特异性 T 细胞反应在感染后六个月内得以保留。
The immune response to SARS-CoV-2 is critical in controlling disease but there is concern that waning immunity may predispose to re-infection. We analysed the magnitude and phenotype of the SARS-CoV-2-specific T cell response in 100 donors at six months following infection. T-cell responses were present by ELISPOT and/or ICS analysis in all donors and characterised by predominant CD4+ T cell responses with strong IL-2 cytokine expression. Median T-cell responses were 50% higher in donors who had experienced a symptomatic infection indicating that the severity of primary infection establishes a ‘setpoint’ for cellular immunity. T-cell responses to spike and nucleoprotein/membrane proteins were correlated with peak antibody levels. Furthermore, higher levels of nucleoprotein-specific T cells were associated with preservation of NP-specific antibody level although no such correlation was observed in relation to spike-specific responses. In conclusion, our data are reassuring that functional SARS-CoV-2-specific T-cell responses are retained at six months following infection.
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影响因子：
5.4
作者：
Figueiredo-Campos P;Blankenhaus B;Mota C;Gomes A;Serrano M;Ariotti S;Costa C;Nunes-Cabaço H;Mendes AM;Gaspar P;Pereira-Santos MC;Rodrigues F;Condeço J;Escoval MA;Santos M;Ramirez M;Melo-Cristino J;Simas JP;Vasconcelos E;Afonso Â;Veldhoen M
通讯作者：
Veldhoen M
影响因子：
6.4
作者：
Guthmiller JJ;Stovicek O;Wang J;Changrob S;Li L;Halfmann P;Zheng NY;Utset H;Stamper CT;Dugan HL;Miller WD;Huang M;Dai YN;Nelson CA;Hall PD;Jansen M;Shanmugarajah K;Donington JS;Krammer F;Fremont DH;Joachimiak A;Kawaoka Y;Tesic V;Madariaga ML;Wilson PC
通讯作者：
Wilson PC
影响因子：
168.9
作者：
Huang, Chaolin;Wang, Yeming;Cao, Bin
通讯作者：
Cao, Bin
影响因子：
11.8
作者：
Payne DC;Iblan I;Rha B;Alqasrawi S;Haddadin A;Al Nsour M;Alsanouri T;Ali SS;Harcourt J;Miao C;Tamin A;Gerber SI;Haynes LM;Al Abdallat MM
通讯作者：
Al Abdallat MM
影响因子：
82.9
作者：
Amanat F;Stadlbauer D;Strohmeier S;Nguyen THO;Chromikova V;McMahon M;Jiang K;Arunkumar GA;Jurczyszak D;Polanco J;Bermudez-Gonzalez M;Kleiner G;Aydillo T;Miorin L;Fierer DS;Lugo LA;Kojic EM;Stoever J;Liu STH;Cunningham-Rundles C;Felgner PL;Moran T;García-Sastre A;Caplivski D;Cheng AC;Kedzierska K;Vapalahti O;Hepojoki JM;Simon V;Krammer F
通讯作者：
Krammer F