Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite.
Effects of hypotension and fluid depletion on central angiotensin-induced thirst and salt appetite.
复制标题
低血压和液体缺乏对中枢血管紧张素引起的口渴和盐食欲的影响。
DOI：
10.1152/ajpregu.2001.281.5.r1726
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Johnson,AK
中科院分区：
文献类型：
--
作者：
Thunhorst,RL;Johnson,AK
我们检查了低血压和液体消耗对大鼠脑室内输注 ANG II 后水和钠摄入的影响。静脉输注血管扩张药物米诺地尔（25 μg·kg−1·min−1）同时静脉输注血管紧张素转换酶抑制剂卡托普利（0.33 mg/min）可产生低血压，以防止内源性 ANG II 形成。低血压会增加对脑室内 ANG II (30 ng/h) 的水摄入量，但不会增加 0.3 M 氯化钠溶液的摄入量，并导致显着的水和钠尿潴留。在脑室内给予 ANG II（15 或 30 ng/h）之前，单独或与卡托普利（皮下注射 100 mg/kg 体重）皮下注射呋塞米（10 mg/kg 体重）可产生急性液体耗竭。液体消耗增加了脑室内 ANG II 最高剂量的水摄入量，但不影响盐水摄入量。在存在卡托普利的情况下，液体消耗增加了对两种剂量的脑室内 ANG II 的水和盐水的摄入量。由于卡托普利给药会导致液体耗尽的动物发生低血压，因此这两个实验的结果表明，液体充足的动物中的低血压会优先增加水摄入量以响应脑室内 ANG II，而液体耗尽的动物则会增加盐和水的摄入量以响应脑室内 ANG II。
We examined the effects of hypotension and fluid depletion on water and sodium ingestion in rats in response to intracerebroventricular infusions of ANG II. Hypotension was produced by intravenous infusion of the vasodilator drug minoxidil (25 μg · kg−1· min−1) concurrently with the angiotensin-converting enzyme inhibitor captopril (0.33 mg/min) to prevent endogenous ANG II formation. Hypotension increased water intake in response to intracerebroventricular ANG II (30 ng/h) but not intake of 0.3 M NaCl solution and caused significant urinary retention of water and sodium. Acute fluid depletion was produced by subcutaneous injections of furosemide (10 mg/kg body wt) either alone or with captopril (100 mg/kg body wt sc) before intracerebroventricular ANG II (15 or 30 ng/h) administration. Fluid depletion increased water intake in response to the highest dose of intracerebroventricular ANG II but did not affect saline intake. In the presence of captopril, fluid depletion increased intakes of both water and saline in response to both doses of intracerebroventricular ANG II. Because captopril administration causes hypotension in fluid-depleted animals, the results of the two experiments suggest that hypotension in fluid-replete animals preferentially increases water intake in response to intracerebroventricular ANG II and in fluid-depleted animals increases both salt and water intake in response to intracerebroventricular ANG II.
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影响因子：
5.5
作者：
CHIARAVIGLIO, E
通讯作者：
CHIARAVIGLIO, E
影响因子：
5.5
作者：
BRYANT, RW;EPSTEIN, AN;FLUHARTY, SJ
通讯作者：
FLUHARTY, SJ
DOI：
10.1152/ajpregu.1994.267.5.r1168
发表时间：
1994-11
期刊：
The American journal of physiology
影响因子：
--
作者：
R. Thunhorst;M. Morris;A. K. Johnson
通讯作者：
R. Thunhorst;M. Morris;A. K. Johnson
影响因子：
5.5
作者：
AVRITH, DB;FITZSIMONS, JT
通讯作者：
FITZSIMONS, JT
钠食欲。
影响因子：
6.1
作者：
E. Stricker;J. Verbalis
通讯作者：
J. Verbalis