DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.

DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.
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DOI:
10.1016/j.it.2011.08.001
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发表时间:
2011-11
影响因子:
16.8
通讯作者:
Yewdell JW
Yewdell JW
中科院分区:
医学1区
文献类型:
--
作者:
Yewdell JW

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缺陷核糖体产物(DRiP)是快速降解的多肽的子集,其为MHC I类分子提供肽配体。在这里,我回顾最近的进展,了解DRiP生物成因。这些发现将DRiP置于MHC I类抗原加工途径的中心,将病毒和肿瘤的免疫监视与专门的翻译和细胞区室化机制联系起来。DRiP使免疫系统能够快速灵敏地检测细胞基因表达的变化。
Defective Ribosomal Products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for MHC class I molecules. Here, I review recent progress in understanding DRiP biogenesis. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly and sensitively detect alterations in cellular gene expression.
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