DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.
DRiPs solidify: progress in understanding endogenous MHC class I antigen processing.
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DOI:
10.1016/j.it.2011.08.001
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发表时间:
2011-11
影响因子:
16.8
通讯作者:
Yewdell JW
中科院分区:
文献类型:
--
作者:
Yewdell JW
Defective Ribosomal Products (DRiPs) are a subset of rapidly degraded polypeptides that provide peptide ligands for MHC class I molecules. Here, I review recent progress in understanding DRiP biogenesis. These findings place DRiPs at the center of the MHC class I antigen processing pathway, linking immunosurveillance of viruses and tumors to mechanisms of specialized translation and cellular compartmentalization. DRiPs enable the immune system to rapidly and sensitively detect alterations in cellular gene expression.
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DOI:
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发表时间:
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期刊:
The Journal of experimental medicine
影响因子:
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Yewdell, JW
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