Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam
Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam
复制标题
锂和毛果芸香碱诱发的癫痫持续状态对地西泮治疗的反应
DOI：
10.1016/0014-4886(88)90010-6
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发表时间：
1988
影响因子：
5.3
通讯作者：
D. Treiman
中科院分区：
文献类型：
--
作者：
N. Walton;D. Treiman
用氯化锂3 mmol/kg，24 h后注射匹罗卡品25 mg/kg，建立大鼠癫痫持续状态（SE）模型。在观察到以下四种EEG模式时开始20 mg/kg地西泮给药：（i）离散电描记癫痫发作;（ii）癫痫样活动增强和减弱;（iii）连续、高振幅、快速尖峰;和（iv）相对平坦背景上的周期性癫痫样放电（PED）。地西泮在停止所有癫痫发作活动方面的成功是通过治疗时观察到的EEG模式预测的。所有接受治疗的大鼠在显示离散电描记癫痫发作时，状态均用地西泮停止，但只有6只中的3只具有癫痫样活动的增强和减弱，6只中的1只具有连续尖峰和PED。持续惊厥大鼠注射安定后峰电位振幅下降74.8 ± 18.25%。这些数据证实了临床印象，即癫痫持续状态持续时间越长，越难以控制，并表明治疗时的EEG模式可预测成功的概率。
Status epilepticus (SE) was induced in rats by administration of 3 mmol/kg lithium chloride followed 24 h later by injection of 25 mg/kg pilocarpine. Treatment with 20 mg/kg diazepam was initiated at the time each of four EEG patterns was seen: (i) discrete electrographic seizures; (ii) waxing and waning epileptiform activity; (iii) continuous, high-amplitude, rapid spiking; and (iv) periodic epileptiform discharges (PEDs) on a relatively flat background. Success of diazepam in stopping all seizure activity was predicted by the EEG pattern seen at the time of treatment. All rats treated while displaying discrete electrographic seizures had status stopped with diazepam, but only three of six with waxing and waning epileptiform activity and one of six each with continuous spiking and PEDs. Rats which continued to seize had a decrease in spike amplitude of 74.8 ± 18.25% following diazepam injection. These data confirm the clinical impression that the longer the duration of status epilepticus, the more difficult it is to control and suggest that the EEG pattern at the time of treatment predicts the probability of success.
影响因子：
56.9
作者：
HONCHAR, MP;OLNEY, JW;SHERMAN, WR
通讯作者：
SHERMAN, WR