Knowledge and attitude of hereditary breast cancer among Japanese university female students
Knowledge and attitude of hereditary breast cancer among Japanese university female students
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日本女大学生遗传性乳腺癌知识与态度调查
DOI：
10.1038/s10038-020-0743-9
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发表时间：
2020
影响因子：
3.5
通讯作者：
Yoshida Masayuki
中科院分区：
文献类型：
--
作者：
Terui-Kohbata Hiroko;Egawa Makiko;Yura Kei;Yoshida Masayuki
BRCA 1/2基因检测使用PARP抑制剂治疗乳腺癌有可能在患者未受影响的年轻家庭成员中出现“继发性发现”，这使他们成为遗传性乳腺癌的风险人群。现在需要对遗传性癌症的背景有适当的了解，才能适当地接受这种风险。因此，我们调查了日本年轻女性对遗传性乳腺癌的知识水平和态度。研究对象为20 - 30岁的日本大学女性，无乳腺癌病史。对他们进行了匿名自答问卷调查。我们收到了353名妇女的答复。知识、意识和兴趣水平相对较高。有乳腺癌家族史的女性比无乳腺癌家族史的女性更不可能接受检测（92.8%对74.5%，p < 0.001）。医学专业对降低风险乳房切除术（RRM）和降低风险输卵管卵巢切除术（RRSO）的阳性反应率显著高于其他专业（RRM：医学71. 6% vs.科学54. 5% vs.人文53.8%，p = 0.008; RRSO：35. 4% vs. 36. 3% vs. 48.4%，p = 0.027）。大约一半的受访者回答，如果他们是BRCA 1/2突变携带者，他们会犹豫结婚（45.3%）或生孩子（55.4%）。这些结果可能有助于建立支持年轻女性生殖决策的方法，这些年轻女性意外地被标记为有HBOC风险。
BRCA1/2genetic testing to use PARP inhibitor for breast cancer has a possibility of the “secondary finding” among the younger nonaffected family members of the patient, which turns them into at-risk for hereditary breast cancer. Proper understanding of the background of the hereditary cancer is now required for appropriate acceptance of the risk. Therefore, we investigated the level of knowledge and attitudes of younger women on hereditary breast cancer in Japan. Study subject was Japanese university women between 20 and 30 years of age, without medical history of breast cancer. We conducted the anonymous self-answering questionnaire to them. We received responses from 353 women. The levels of knowledge, awareness, and interest were relatively high. Women with a family history of breast cancer were less likely to undergo testing than women without (92.8% vs. 74.5%,p< 0.001). The rates of positive response toward risk-reducing mastectomy (RRM) and risk-reducing salpingo-oophorectomy (RRSO) was significantly high for medical majors compared with that for other majors (RRM: medical 71.6% vs. science 54.5% vs. humanities 53.8%,p= 0.008, RRSO: 35.4% vs. 36.3% vs. 48.4%,p= 0.027). Approximately half of respondents answered that they would hesitate to get married (45.3%) or to have children (55.4%), if they were aBRCA1/2mutation carrier. The results may help to establish the methods for supporting the decision-making for reproduction of younger women who are unexpectedly labeled as being at-risk for HBOC.
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影响因子：
2.2
作者：
Morgan, Debra;Sylvester, Heather;Miesfeldt, Susan
通讯作者：
Miesfeldt, Susan
日本遗传性乳腺癌和卵巢癌遗传咨询的障碍
DOI：
10.4091/iken.2017.003
发表时间：
2017
期刊：
Iryo To Shakai
影响因子：
--
作者：
甲畑（照井） 宏子;四元 淳子;青木 美保;大石 陽子;内田 信之;赤木 究;吉田 雅幸
通讯作者：
吉田 雅幸
年轻女性乳腺癌幸存者利用遗传咨询和风险评估服务的障碍和促进因素。
影响因子：
1.8
作者：
Anderson B;McLosky J;Wasilevich E;Lyon-Callo S;Duquette D;Copeland G
通讯作者：
Copeland G
影响因子：
2.1
作者：
Forman, Andrea D.;Hall, Michael J.
通讯作者：
Hall, Michael J.