Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601
Autologous cytolytic T lymphocytes recognize a MAGE‐1 nonapeptide on melanomas expressing HLA‐Cw* 1601
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自体溶细胞 T 淋巴细胞识别表达 HLA-Cw* 的黑色素瘤上的 MAGE-1 九肽 1601
DOI：
10.1002/eji.1830240930
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发表时间：
1994
影响因子：
5.4
通讯作者：
T. Boon
中科院分区：
文献类型：
--
作者：
P. Bruggen;J. Szikora;P. Boël;C. Wildmann;M. Somville;M. Sensi;T. Boon
Human melanoma cell line MZ2‐MEL expresses several antigens recognized by autologous cytolytic T lymphocyte (CTL) clones. We reported previously the identification of a gene, named MAGE‐1, which codes for antigen MZ2‐E which is presented by HLA‐A1. Gene MAGE‐1 is expressed in many tumors of several types but not in normal tissues except for testis. We show here that gene MAGE‐1 directs the expression of another antigen recognized by CTL on the MZ2‐MEL cells. This antigen, which was named MZ2‐Bb, consists of MAGE‐1‐encoded peptide SAYGEPRKL bound to major histocompatibility molecule HLA‐Cw* 1601. The HLA‐Cw* 1601 allele was found to be expressed by 7 out of 99 individuals from a Caucasian population. Our results extend the range of tumor patients who could be eligible for immunization against MAGE antigens.
对自体黑色素瘤细胞具有特异性的人细胞毒性 T 细胞：连续七例从淋巴结细胞成功生成。
DOI：
10.1093/jnci/80.13.1016
发表时间：
1988
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
SlingluffJr,CL;Darrow,T;Vervaert,C;Quinn-Allen,MA;Seigler,HF
通讯作者：
Seigler,HF
影响因子：
2.7
作者：
CHEN, BP;LAM, V;SONDEL, PM
通讯作者：
SONDEL, PM
DOI：
10.1073/pnas.91.6.2105
发表时间：
1994-03-15
影响因子：
11.1
作者：
CELIS, E;TSAI, V;SERRA, HM
通讯作者：
SERRA, HM