Phospho.ELM: a database of phosphorylation sites--update 2008.

Phospho.ELM: a database of phosphorylation sites--update 2008.
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DOI:
10.1093/nar/gkm772
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发表时间:
2008-01
影响因子:
14.9
通讯作者:
Gibson TJ
Gibson TJ
中科院分区:
生物学2区
文献类型:
--
作者:
Diella F;Gould CM;Chica C;Via A;Gibson TJ

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ELM是一个人工管理的真核细胞磷酸化位点数据库。该资源包括从已发表的文献和高通量数据集中收集的数据。目前发布的Phosph.ELM(版本7.0,2007年7月)包含4078个磷酸蛋白质序列,涵盖12025个磷酸丝氨酸、2362个磷酸苏氨酸和2083个磷酸酪氨酸位点。这些条目提供了有关磷酸化蛋白质的信息和已知的磷酸化实例的确切位置,负责修饰的激酶(如果已知)以及到参考文献的链接。数据库条目有超链接,可以方便地访问来自UniProt、PubMed、SMART、ELM、MSD的进一步信息,以及到蛋白质相互作用数据库MINT和STRING的链接。一种新的BLAST搜索工具,作为对按关键字和UniProt登录号检索的补充,允许用户提交蛋白质查询(按序列或UniProt登录号),以针对磷酸化肽的精选数据集进行搜索。PhosPho.ELM可在网上获得,网址为:http://phospho.elm.eu.org
Phospho.ELM is a manually curated database of eukaryotic phosphorylation sites. The resource includes data collected from published literature as well as high-throughput data sets. The current release of Phospho.ELM (version 7.0, July 2007) contains 4078 phospho-protein sequences covering 12 025 phospho-serine, 2362 phospho-threonine and 2083 phospho-tyrosine sites. The entries provide information about the phosphorylated proteins and the exact position of known phosphorylated instances, the kinases responsible for the modification (where known) and links to bibliographic references. The database entries have hyperlinks to easily access further information from UniProt, PubMed, SMART, ELM, MSD as well as links to the protein interaction databases MINT and STRING. A new BLAST search tool, complementary to retrieval by keyword and UniProt accession number, allows users to submit a protein query (by sequence or UniProt accession) to search against the curated data set of phosphorylated peptides. Phospho.ELM is available on line at: http://phospho.elm.eu.org
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