STRING 7--recent developments in the integration and prediction of protein interactions.
STRING 7--recent developments in the integration and prediction of protein interactions.
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DOI：
10.1093/nar/gkl825
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Bork P
中科院分区：
文献类型：
--
作者：
von Mering C;Jensen LJ;Kuhn M;Chaffron S;Doerks T;Krüger B;Snel B;Bork P
有关蛋白质 - 蛋白质相互作用的信息仍然大多局限于少数模式生物，并且来自各种各样的实验和计算技术。数据库和在线资源STRING通过整合来自多种来源的已知和预测的相互作用，使蛋白质相互作用数据更易于获取。其底层基础设施包括一组完整测序的基因组以及详尽的直系同源分类，基于这些，相互作用的证据可在生物之间转移。尽管该资源主要是为蛋白质相互作用分析而开发的，但它也已成功应用于比较基因组学、系统发育学和网络研究，通过对数据库后端的编程访问以及紧凑下载文件的可用性，这些研究都得到了促进。截至第7版，STRING涵盖的不同生物几乎增加了一倍，达到373种，并且包含超过150万个已预先计算其关联的蛋白质。新特性包括基于AJAX的网络导航、纳入诸如BioGRID等其他资源以及详细的蛋白质结构域注释。STRING可在以下网址获取：
Information on protein–protein interactions is still mostly limited to a small number of model organisms, and originates from a wide variety of experimental and computational techniques. The database and online resource STRING generalizes access to protein interaction data, by integrating known and predicted interactions from a variety of sources. The underlying infrastructure includes a consistent body of completely sequenced genomes and exhaustive orthology classifications, based on which interaction evidence is transferred between organisms. Although primarily developed for protein interaction analysis, the resource has also been successfully applied to comparative genomics, phylogenetics and network studies, which are all facilitated by programmatic access to the database backend and the availability of compact download files. As of release 7, STRING has almost doubled to 373 distinct organisms, and contains more than 1.5 million proteins for which associations have been pre-computed. Novel features include AJAX-based web-navigation, inclusion of additional resources such as BioGRID, and detailed protein domain annotation. STRING is available at
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影响因子：
6.8
作者：
Valencia, A;Pazos, F
通讯作者：
Pazos, F
影响因子：
13.8
作者：
Dandekar, T;Snel, B;Bork, P
通讯作者：
Bork, P
影响因子：
14.9
作者：
Neduva V;Russell RB
通讯作者：
Russell RB
DOI：
10.1073/pnas.96.8.4285
发表时间：
1999-04-13
影响因子：
11.1
作者：
Pellegrini, M;Marcotte, EM;Yeates, TO
通讯作者：
Yeates, TO
影响因子：
14.9
作者：
Rattei, Thomas;Arnold, Roland;Tischler, Patrick;Lindner, Dominik;Stumpflen, Volker;Mewes, H. Werner
通讯作者：
Mewes, H. Werner