Acute effects of ambient ozone on mortality in Europe and North America: results from the APHENA study.
Acute effects of ambient ozone on mortality in Europe and North America: results from the APHENA study.
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DOI：
10.1007/s11869-012-0180-9
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发表时间：
2013-06-01
影响因子：
5.1
通讯作者：
Samet, Jonathan M.
中科院分区：
文献类型：
--
作者：
Peng, Roger D.;Samoli, Evangelia;Luu Pham;Dominici, Francesca;Touloumi, Giota;Ramsay, Tim;Burnett, Richard T.;Krewski, Daniel;Le Tertre, Alain;Cohen, Aaron;Atkinson, Richard W.;Anderson, H. Ross;Katsouyanni, Klea;Samet, Jonathan M.
“空气污染与健康：欧洲和北美相结合的方法”（APHENA）项目是对关于空气污染与不良健康结果之间关系的多城市时间序列数据的协作分析。 APHENA 的主要目标是检验欧洲、美国和加拿大 125 个城市的空气污染水平短期波动与死亡率和发病率之间的时间序列研究结果的一致性。使用两阶段方法进行多城市时间序列分析。我们使用泊松回归模型通过惩罚样条或自然样条来控制过度离散，以调整季节性。使用分层模型来获得与臭氧相关的超额死亡率的总体估计并评估潜在的影响修改。潜在影响因素是与其他环境空气污染物暴露、天气、社会经济状况和人口脆弱性相关的城市特征。欧洲和美国的区域汇总风险估计相似；来自加拿大的比例要高得多。与 1 小时每日最大 O3 增加 10 µg/m3 相关的汇总估计超额相对风险为 0.26%（95% CI，0.15%，0.37%）。在各个地区，年龄或分析中考虑的其他影响因素对影响的影响几乎没有一致的迹象。 APHENA 关于 O3 对普通人群死亡率影响的研究结果与之前报道的结果相当，并且数据分析方法相对稳健。总体而言，没有迹象表明分析中考虑的年龄或生态变量会产生强烈的影响。
The “Air Pollution and Health: A Combined European and North American Approach” (APHENA) project is a collaborative analysis of multi-city time-series data on the association between air pollution and adverse health outcomes. The main objective of APHENA was to examine the coherence of findings of time-series studies relating short-term fluctuations in air pollution levels to mortality and morbidity in 125 cities in Europe, the US, and Canada. Multi-city time-series analysis was conducted using a two-stage approach. We used Poisson regression models controlling for overdispersion with either penalized or natural splines to adjust for seasonality. Hierarchical models were used to obtain an overall estimate of excess mortality associated with ozone and to assess potential effect modification. Potential effect modifiers were city-level characteristics related to exposure to other ambient air pollutants, weather, socioeconomic status, and the vulnerability of the population. Regionally pooled risk estimates from Europe and the US were similar; those from Canada were substantially higher. The pooled estimated excess relative risk associated with a 10 µg/m3 increase in 1 h daily maximum O3 was 0.26 % (95 % CI, 0.15 %, 0.37 %). Across regions, there was little consistent indication of effect modification by age or other effect modifiers considered in the analysis. The findings from APHENA on the effects of O3 on mortality in the general population were comparable with previously reported results and relatively robust to the method of data analysis. Overall, there was no indication of strong effect modification by age or ecologic variables considered in the analysis.
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影响因子：
10.4
作者：
Samoli, Evangelia;Peng, Roger;Ramsay, Tim;Pipikou, Marina;Touloumi, Giota;Dominici, Francesca;Burnett, Rick;Cohen, Aaron;Krewski, Daniel;Samet, Jon;Katsouyanni, Klea
通讯作者：
Katsouyanni, Klea
DOI：
10.3200/aeoh.59.5.228-236
发表时间：
2004-05-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
Burnett, RT;Stieb, D;Dann, T
通讯作者：
Dann, T
DOI：
10.1007/bf03404464
发表时间：
1998-05-01
影响因子：
4.3
作者：
Burnett, RT;Cakmak, S;Brook, JR
通讯作者：
Brook, JR
DOI：
10.1198/016214504000000980
发表时间：
2004-09-01
影响因子：
3.7
作者：
Wood, SN
通讯作者：
Wood, SN
DOI：
10.1097/ede.0b013e3181aba749
发表时间：
2009-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Bell ML;Ebisu K;Peng RD;Dominici F
通讯作者：
Dominici F