Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study.
Acute effects of ambient particulate matter on mortality in Europe and North America: results from the APHENA study.
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DOI：
10.1289/ehp.11345
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发表时间：
2008-11
影响因子：
10.4
通讯作者：
Katsouyanni, Klea
中科院分区：
文献类型：
--
作者：
Samoli, Evangelia;Peng, Roger;Ramsay, Tim;Pipikou, Marina;Touloumi, Giota;Dominici, Francesca;Burnett, Rick;Cohen, Aaron;Krewski, Daniel;Samet, Jon;Katsouyanni, Klea
关键词：
APHENA（空气污染与健康：欧洲和北美联合方法）研究是对空气污染对人口健康影响的多城市时间序列数据的协作分析，汇集了欧洲APHEA（空气污染与健康：欧洲方法）和美国的数据NMMAPS（国家发病率、死亡率和空气污染研究）项目，沿着的还有加拿大的数据。APHENA的主要目的是评估在欧洲和北美进行的多城市研究结果的一致性，当使用共同的协议进行分析时，并探索可能的异质性来源。我们介绍了APHENA关于空气动力学直径（PM10）≤ 10 μm的颗粒物（PM）对所有年龄段以及< 75岁和≥ 75岁人群每日死亡人数的影响的结果。我们探讨了可能改变这种关联的潜在环境和社会经济因素的影响。在两阶段分析的第一阶段，我们使用泊松回归模型，自然和惩罚样条，以调整季节性，具有不同的自由度。在第二阶段，我们使用元回归方法来结合联合收割机的时间序列的结果，跨城市，并评估选定的生态协变量的影响修改。不同的建模方法对空气污染风险的估计相对稳健。欧洲和美国的风险估计值相似，但加拿大的风险估计值要高得多。对于有每日空气污染数据的城市，PM10对所有年龄段全因死亡率的综合影响范围为0.2%至0.6%，环境PM10浓度增加10 μg/m3。其他污染物和气候变量的影响修正在欧洲和美国各不相同。在这两个地区，老年人比例较高和失业率较高与空气污染风险增加有关。基于APHENA研究的与PM空气污染相关的死亡率增加的估计与以前的报告结果大致相当。总体而言，欧洲和美国的风险估计值相似，但加拿大的风险估计值较高。然而，欧洲和美国的PM10效应修正模式略有不同。
The APHENA (Air Pollution and Health: A Combined European and North American Approach) study is a collaborative analysis of multicity time-series data on the effect of air pollution on population health, bringing together data from the European APHEA (Air Pollution and Health: A European Approach) and U.S. NMMAPS (National Morbidity, Mortality and Air Pollution Study) projects, along with Canadian data. The main objective of APHENA was to assess the coherence of the findings of the multicity studies carried out in Europe and North America, when analyzed with a common protocol, and to explore sources of possible heterogeneity. We present APHENA results on the effects of particulate matter (PM) ≤ 10 μm in aerodynamic diameter (PM10) on the daily number of deaths for all ages and for those < 75 and ≥ 75 years of age. We explored the impact of potential environmental and socioeconomic factors that may modify this association. In the first stage of a two-stage analysis, we used Poisson regression models, with natural and penalized splines, to adjust for seasonality, with various degrees of freedom. In the second stage, we used meta-regression approaches to combine time-series results across cites and to assess effect modification by selected ecologic covariates. Air pollution risk estimates were relatively robust to different modeling approaches. Risk estimates from Europe and United States were similar, but those from Canada were substantially higher. The combined effect of PM10 on all-cause mortality across all ages for cities with daily air pollution data ranged from 0.2% to 0.6% for a 10-μg/m3 increase in ambient PM10 concentration. Effect modification by other pollutants and climatic variables differed in Europe and the United States. In both of these regions, a higher proportion of older people and higher unemployment were associated with increased air pollution risk. Estimates of the increased mortality associated with PM air pollution based on the APHENA study were generally comparable with results of previous reports. Overall, risk estimates were similar in Europe and in the United States but higher in Canada. However, PM10 effect modification patterns were somewhat different in Europe and the United States.
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影响因子：
10.4
作者：
O'Neill MS;Jerrett M;Kawachi I;Levy JI;Cohen AJ;Gouveia N;Wilkinson P;Fletcher T;Cifuentes L;Schwartz J;Workshop on Air Pollution and Socioeconomic Conditions
通讯作者：
Workshop on Air Pollution and Socioeconomic Conditions
影响因子：
105.7
作者：
Katsouyanni, K;Touloumi, G;Anderson, HR
通讯作者：
Anderson, HR
DOI：
10.1007/bf03404464
发表时间：
1998-05-01
影响因子：
4.3
作者：
Burnett, RT;Cakmak, S;Brook, JR
通讯作者：
Brook, JR
DOI：
10.1198/016214502753479266
发表时间：
2002-03-01
影响因子：
3.7
作者：
Dominici, F;Daniels, M;Samet, JM
通讯作者：
Samet, JM
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N