Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival.
Expression of LDL receptor-related proteins (LRPs) in common solid malignancies correlates with patient survival.
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DOI：
10.1371/journal.pone.0186649
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发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Gilder AS
中科院分区：
文献类型：
--
作者：
Gonias SL;Karimi-Mostowfi N;Murray SS;Mantuano E;Gilder AS
低密度脂蛋白受体相关蛋白(LRPs)是一种跨膜受体，参与细胞内吞作用、细胞信号传递和其他细胞蛋白的运输。相当多的工作集中在血管生物学和神经生物学领域的LRPs。这些受体如何影响人类的癌症进展在很大程度上仍不清楚。在这里，我们挖掘了癌症基因组图谱(TCGA)中的临时数据库，比较了13个LRP在10种常见的实体恶性肿瘤患者中的表达。我们的第一个目标是确定每种癌症中LRP mRNAs的丰度。我们的第二个目标是确定LRP的表达是否与患者生存的改善或恶化有关。总共挖掘了4629名患者的数据。在所研究的10种癌症中，LRP表达最丰富的是LRP1；然而，只有在膀胱尿路上皮癌中才观察到LRP1的mRNA表达与患者生存的相关性。在这种恶性肿瘤中，LRP1mRNA的高水平与患者存活率的恶化有关。低密度脂蛋白受体(LDLR)的高水平与胰腺癌患者生存率降低有关。在肝细胞癌、肺腺癌和胰腺癌中，LRP10基因的高水平与患者存活率降低有关。LRP2是唯一一个高水平的信使核糖核酸表达与改善患者存活率相关的LRP。这种相关性在肾透明细胞癌中观察到。深入了解LRP基因在人类癌症中的表达及其对患者生存的影响将指导未来的研究。
LDL receptor-related proteins (LRPs) are transmembrane receptors involved in endocytosis, cell-signaling, and trafficking of other cellular proteins. Considerable work has focused on LRPs in the fields of vascular biology and neurobiology. How these receptors affect cancer progression in humans remains largely unknown. Herein, we mined provisional databases in The Cancer Genome Atlas (TCGA) to compare expression of thirteen LRPs in ten common solid malignancies in patients. Our first goal was to determine the abundance of LRP mRNAs in each type of cancer. Our second goal was to determine whether expression of LRPs is associated with improved or worsened patient survival. In total, data from 4,629 patients were mined. In nine of ten cancers studied, the most abundantly expressed LRP was LRP1; however, a correlation between LRP1 mRNA expression and patient survival was observed only in bladder urothelial carcinoma. In this malignancy, high levels of LRP1 mRNA were associated with worsened patient survival. High levels of LDL receptor (LDLR) mRNA were associated with decreased patient survival in pancreatic adenocarcinoma. High levels of LRP10 mRNA were associated with decreased patient survival in hepatocellular carcinoma, lung adenocarcinoma, and pancreatic adenocarcinoma. LRP2 was the only LRP for which high levels of mRNA expression correlated with improved patient survival. This correlation was observed in renal clear cell carcinoma. Insights into LRP gene expression in human cancers and their effects on patient survival should guide future research.
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影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
LDLR相关的蛋白10（LRP10）调节淀粉样蛋白前体蛋白（APP）运输和加工：在阿尔茨海默氏病中作用的证据。
影响因子：
15.1
作者：
Brodeur J;Thériault C;Lessard-Beaudoin M;Marcil A;Dahan S;Lavoie C
通讯作者：
Lavoie C
影响因子：
2.7
作者：
Lee, Ju-Dong;Jung, Haiyoung;Min, Sang-Hyun
通讯作者：
Min, Sang-Hyun
影响因子：
11.2
作者：
Lindner, Inge;Hemdan, Nasr Y. A.;Birkenmeier, Gerd
通讯作者：
Birkenmeier, Gerd
影响因子：
64.5
作者：
Ceccarelli M;Barthel FP;Malta TM;Sabedot TS;Salama SR;Murray BA;Morozova O;Newton Y;Radenbaugh A;Pagnotta SM;Anjum S;Wang J;Manyam G;Zoppoli P;Ling S;Rao AA;Grifford M;Cherniack AD;Zhang H;Poisson L;Carlotti CG Jr;Tirapelli DP;Rao A;Mikkelsen T;Lau CC;Yung WK;Rabadan R;Huse J;Brat DJ;Lehman NL;Barnholtz-Sloan JS;Zheng S;Hess K;Rao G;Meyerson M;Beroukhim R;Cooper L;Akbani R;Wrensch M;Haussler D;Aldape KD;Laird PW;Gutmann DH;TCGA Research Network;Noushmehr H;Iavarone A;Verhaak RG
通讯作者：
Verhaak RG