Endomorphin-1, effects on male sexual behavior
Endomorphin-1, effects on male sexual behavior
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Endomorphin-1，对男性性行为的影响
DOI：
10.1016/j.physbeh.2009.02.004
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发表时间：
2009
影响因子：
2.9
通讯作者：
R. Paredes
中科院分区：
文献类型：
--
作者：
L. Parra;A. García;Alberto Salazar;Benito Antón;R. Paredes
我们研究了内源性阿片肽内啡肽-1 （EM-1）对雄性交配行为的影响，EM-1是一种选择性结合μ受体的内源性阿片肽。在第一个实验中，脑室内注射四种剂量的EM-1（1、10、50和100 μM）显著增加了射精潜伏期和射精间隔，并减少了射精次数。实验2在脑室注射EM-1 （100 μM）前30 min用纳洛酮（5 mg/kg）预处理完全阻断EM-1的作用。这些结果表明，EM-1对μ受体的激活改变了与射精相关的参数（增加射精潜伏期和减少射精次数），证实了阿片类药物在性行为中释放。
We examined the effect of endomorphin-1 (EM-1), an endogenous opioid peptide that binds selectively to the μ receptor, on male copulatory behavior in sexually vigorous Wistar rats. In the first experiment, four doses of EM-1 (1, 10, 50, and 100 μM) injected intracerebroventricularly produced a marked increase in ejaculation latency and interintromission interval and reduced the number of ejaculations during the test. In experiment 2 the effects of EM-1 were completely blocked by pretreatment with naloxone (5 mg/kg) 30 min prior to intracerebroventricular injection of EM-1 (100 μM). Collectively these results indicate that the activation of μ receptors by EM-1 modifies parameters associated with ejaculation (increases ejaculation latency and reduces the number of ejaculations) confirming that opioids are released during sexual behavior.
将 mu-阿片受体激动剂内吗啡肽 2（而非内吗啡肽 1）显微注射到大鼠杏仁核中心内侧诱导的反常痛觉过敏。
影响因子：
5
作者：
Terashvili,Maia;Wu,Hsiang-En;Schwasinger,Emma;Tseng,LeonF
通讯作者：
Tseng,LeonF
影响因子：
2.5
作者：
Martin-Schild, S;Gerall, AA;Zadina, JE
通讯作者：
Zadina, JE