White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study
White matter abnormalities across different epilepsy syndromes in adults: an ENIGMA Epilepsy study
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成人不同癫痫综合征的白质异常：ENIGMA 癫痫研究
DOI：
10.1101/2019.12.19.883405
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
C. McDonald
中科院分区：
文献类型：
--
作者：
S. Hatton;Khoa H Huynh;L. Bonilha;E. Abela;S. Alhusaini;A. Altmann;M. Alvim;A. Balachandra;E. Bartolini;B. Bender;N. Bernasconi;A. Bernasconi;B. Bernhardt;N. Bargalló;B. Caldairou;M. Caligiuri;Sarah J. A. Carr;G. Cavalleri;F. Cendes;L. Concha;E. Davoodi;P. Desmond;O. Devinsky;C. Doherty;M. Domin;J. Duncan;N. Focke;S. Foley;A. Gambardella;E. Gleichgerrcht;R. Guerrini;K. Hamandi;Akari Ishikawa;S. Keller;P. Kochunov;R. Kotikalapudi;Barbara A. K. Kreilkamp;P. Kwan;A. Labate;S. Langner;M. Lenge;Min Liu;Elaine H. Lui;Pascal Martin;M. Mascalchi;J. Moreira;M. Morita;T. O’Brien;H. Pardoe;J. Pariente;L. Ribeiro;M. Richardson;C. Rocha;Raúl Rodríguez;F. Rosenow;M. Severino;B. Sinclair;H. Soltanian;P. Striano;P. Taylor;R. Thomas;D. Tortora;D. Velakoulis;A. Vezzani;Lucy E Vivash;F. von Podewils;S. Vos;B. Weber;G. Winston;C. Yasuda;P. Thompson;N. Jahanshad;S. Sisodiya;C. McDonald
癫痫通常伴有脑白质的广泛异常。 ENIGMA-Epilepsy 是一个大型定量脑成像联盟，汇总数据以研究常见癫痫综合征的神经影像异常模式，包括颞叶癫痫、颞外癫痫和遗传性全身性癫痫。我们的目标是对成年癫痫患者的多中心样本中综合症之间和综合症内最显着的白质微观结构差异进行排名。对 1,069 名非癫痫对照者和 1,249 名患者的弥散加权 MRI 数据进行了分析：伴海马硬化的颞叶癫痫 (N=599)、MRI 正常的颞叶癫痫 (N=275)、遗传性全身性癫痫 (N=182) 和非病变性颞外癫痫 (N=193)。使用基于束的空间统计的统一协议来导出每个参与者的分数各向异性和平均扩散率的骨架图，并使用扩散 MRI 图集对纤维束进行分段。使用批次效应校正工具（ComBat）对数据进行协调，以校正扩散测量中扫描仪特定的变化。协方差分析，调整年龄和性别，检查了每个白质束的每种癫痫综合征和对照之间的差异（Bonferroni 校正为 p<0.001）。在“所有癫痫”中，大多数纤维束中观察到较低的各向异性分数，具有小到中等的效应大小，特别是在胼胝体、扣带带和外囊中。平均扩散率的影响不太明显。症状特异性分数各向异性和平均扩散率差异在海马硬化患者的同侧海马旁扣带回和外囊中最为明显，而对大多数其他束的影响较小。颞叶癫痫和 MRI 正常的患者表现出类似的同侧异常多于对侧异常的模式，但不如海马硬化患者明显。全身性癫痫和颞外癫痫患者的胼胝体、放射冠和外囊的各向异性分数以及放射冠前部的平均扩散率存在显着差异。海马硬化患者癫痫发作年龄较早和病程较长与显微结构异常程度较高相关。我们在一项大型多中心癫痫研究中证明了主要关联纤维、连合纤维和投射纤维的微观结构异常。总体而言，癫痫患者在胼胝体、扣带回和外囊中表现出白质异常，不同癫痫综合征的严重程度不同。这些数据进一步定义了常见癫痫综合征中白质异常的范围，从而对病理基础产生了新的见解，可用于指导未来的治疗和遗传学研究。
The epilepsies are commonly accompanied by widespread abnormalities in cerebral white matter. ENIGMA-Epilepsy is a large quantitative brain imaging consortium, aggregating data to investigate patterns of neuroimaging abnormalities in common epilepsy syndromes, including temporal lobe epilepsy, extratemporal epilepsy, and genetic generalized epilepsy. Our goal was to rank the most robust white matter microstructural differences across and within syndromes in a multicentre sample of adult epilepsy patients. Diffusion-weighted MRI data were analyzed from 1,069 non-epileptic controls and 1,249 patients: temporal lobe epilepsy with hippocampal sclerosis (N=599), temporal lobe epilepsy with normal MRI (N=275), genetic generalized epilepsy (N=182) and nonlesional extratemporal epilepsy (N=193). A harmonized protocol using tract-based spatial statistics was used to derive skeletonized maps of fractional anisotropy and mean diffusivity for each participant, and fiber tracts were segmented using a diffusion MRI atlas. Data were harmonized to correct for scanner-specific variations in diffusion measures using a batch-effect correction tool (ComBat). Analyses of covariance, adjusting for age and sex, examined differences between each epilepsy syndrome and controls for each white matter tract (Bonferroni corrected at p<0.001). Across “all epilepsies” lower fractional anisotropy was observed in most fiber tracts with small to medium effect sizes, especially in the corpus callosum, cingulum and external capsule. Less robust effects were seen with mean diffusivity. Syndrome-specific fractional anisotropy and mean diffusivity differences were most pronounced in patients with hippocampal sclerosis in the ipsilateral parahippocampal cingulum and external capsule, with smaller effects across most other tracts. Those with temporal lobe epilepsy and normal MRI showed a similar pattern of greater ipsilateral than contralateral abnormalities, but less marked than those in patients with hippocampal sclerosis. Patients with generalized and extratemporal epilepsies had pronounced differences in fractional anisotropy in the corpus callosum, corona radiata and external capsule, and in mean diffusivity of the anterior corona radiata. Earlier age of seizure onset and longer disease duration were associated with a greater extent of microstructural abnormalities in patients with hippocampal sclerosis. We demonstrate microstructural abnormalities across major association, commissural, and projection fibers in a large multicentre study of epilepsy. Overall, epilepsy patients showed white matter abnormalities in the corpus callosum, cingulum and external capsule, with differing severity across epilepsy syndromes. These data further define the spectrum of white matter abnormalities in common epilepsy syndromes, yielding new insights into pathological substrates that may be used to guide future therapeutic and genetic studies.
影响因子：
2.1
作者：
Johnson, W. Evan;Li, Cheng;Rabinovic, Ariel
通讯作者：
Rabinovic, Ariel
影响因子：
4.8
作者：
Engel J Jr;Thompson PM;Stern JM;Staba RJ;Bragin A;Mody I
通讯作者：
Mody I
影响因子：
16.6
作者：
Abou-Khalil, Bassel;Auce, Pauls;Zimprich, Fritz
通讯作者：
Zimprich, Fritz