Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance.
Involvement of Anoikis in Dissociated Optic Nerve Fiber Layer Appearance.
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DOI：
10.3390/ijms22041724
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发表时间：
2021-02-09
影响因子：
5.6
通讯作者：
Oku H
中科院分区：
文献类型：
--
作者：
Ikeda T;Nakamura K;Sato T;Kida T;Oku H
分离的视神经纤维层（DONFL）的外观特征是在玻璃体切除术后观察到的眼底凹陷，伴有黄斑疾病的内界膜（ILM）剥离。然而，DONFL的原因在很大程度上仍然未知。光学相干断层扫描（OCT）的结果表明，神经纤维层（NFL）和神经节细胞可能已被损坏的DONFL外观的患者。由于DONFL的出现发生在术后的某个时期，因此不太可能是ILM剥离直接引起的视网膜损伤，因为细胞凋亡发生在组织损伤和/或损伤后的某个时期。然而，这可能是由于ILM剥离诱导的视网膜组织凋亡。失巢凋亡是一种发生在贴壁依赖性细胞中的细胞凋亡，这些细胞与周围的细胞外基质分离（即，细胞锚定的丧失）。据报道，失巢凋亡相关蛋白βA3/A1晶体蛋白和E-cadherin在视网膜神经节细胞中表达。因此，我们推测DONFL出现的一个可能原因是ILM剥离诱导的视网膜神经节细胞失巢凋亡。
Dissociated optic nerve fiber layer (DONFL) appearance is characterized by dimpling of the fundus when observed after vitrectomy with the internal limiting membrane (ILM) peeling in macular diseases. However, the cause of DONFL remains largely unknown. Optical coherence tomography (OCT) findings have indicated that the nerve fiber layer (NFL) and ganglion cells are likely to have been damaged in patients with DONFL appearance. Since DONFL appearance occurs at a certain postoperative period, it is unlikely to be retinal damage directly caused by ILM peeling because apoptosis occurs at a certain period after tissue damage and/or injury. However, it may be due to ILM peeling-induced apoptosis in the retinal tissue. Anoikis is a type of apoptosis that occurs in anchorage-dependent cells upon detachment of those cells from the surrounding extracellular matrix (i.e., the loss of cell anchorage). The anoikis-related proteins βA3/A1 crystallin and E-cadherin are reportedly expressed in retinal ganglion cells. Thus, we theorize that one possible cause of DONFL appearance is ILM peeling-induced anoikis in retinal ganglion cells.
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