SPATA33 functions as a mitophagy receptor in mammalian germline
SPATA33 functions as a mitophagy receptor in mammalian germline
复制标题
SPATA33 在哺乳动物种系中充当线粒体自噬受体
DOI：
10.1080/15548627.2021.1909836
复制
发表时间：
2021-04
期刊：
影响因子：
13.3
通讯作者：
Zhou Rongjia
中科院分区：
文献类型：
--
作者：
Xu Xu;Zhang Ying;Cheng Hanhua;Zhou Rongjia
摘要线粒体自噬是维持细胞内环境稳定的重要机制，通过自噬-溶酶体途径选择性地降解受损或多余的线粒体。我们最近的研究表明，SPATA 33作为一种新的线粒体自噬受体的功能，在启动线粒体降解在男性生殖细胞。SPATA 33直接介导线粒体外膜蛋白VDAC 2与线粒体自噬过程中自噬机制组分ATG 16 L1的相互作用。在饥饿诱导时，SPATA 33可以作为自噬受体促进线粒体自噬。因此，SPATA 33在生殖系细胞中的线粒体自噬期间赋予货物选择性。这些发现为选择性自噬和线粒体稳态提供了新的见解。
ABSTRACT Mitophagy is an essential mechanism in maintaining cellular homeostasis, in which damaged and superfluous mitochondria are selectively degraded by the autophagy-lysosome pathway. Our recent study revealed that SPATA33 functions as a novel receptor for mitophagy in the priming of mitochondria for degradation in male germline cells. SPATA33 directly mediates the interaction of the outer mitochondrial membrane protein VDAC2 with the autophagy machinery component ATG16L1 during mitophagy. Upon starvation induction, SPATA33 can promote mitophagy as an autophagy receptor. Thus, SPATA33 confers cargo selectivity during mitophagy in germline cells. These findings provide new insights into selective autophagy and mitochondrial homeostasis.
SPATA33 是种系线粒体自噬中货物选择性的自噬介体
影响因子：
12.4
作者：
Zhang Y;Xu X;Hu M;Wang X;Cheng H;Zhou R
通讯作者：
Zhou R