Sleep disturbance, inflammation and depression risk in cancer survivors.
Sleep disturbance, inflammation and depression risk in cancer survivors.
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DOI：
10.1016/j.bbi.2012.05.002
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发表时间：
2013-03
影响因子：
15.1
通讯作者：
Hague, Reina
中科院分区：
文献类型：
--
作者：
Irwin, Michael R.;Olmstead, Richard E.;Ganz, Patricia A.;Hague, Reina
在美国1140万癌症幸存者中，超过三分之二的人可以预期长期生存，许多其他人将癌症作为一种慢性疾病，通过持续治疗加以控制。然而，行为共病通常在治疗期间出现并长期存在，使生存复杂化并降低生活质量。在这篇综述中，描述了癌症、抑郁症和睡眠障碍之间的相互关系，重点关注睡眠障碍作为抑郁症危险因素的作用。越来越多的证据也将炎症生物学动力学的改变与癌症诊断和治疗的长期影响联系起来，并讨论了睡眠障碍驱动炎症的假设，这些炎症共同导致抑郁症。更好地了解炎症和行为共病之间的关联有可能改善癌症幸存者睡眠障碍和抑郁症的风险预测和预防和治疗策略的制定。
Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.
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影响因子：
7.6
作者：
Buysse, DJ;Reynolds, CF;Frank, E
通讯作者：
Frank, E
影响因子：
6.6
作者：
Dombrovski, Alexandre Y.;Mulsant, Benoit H.;Reynolds, Charles F., III
通讯作者：
Reynolds, Charles F., III
DOI：
10.1176/appi.ajp.2008.07121882
发表时间：
2008-12
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Cho HJ;Lavretsky H;Olmstead R;Levin MJ;Oxman MN;Irwin MR
通讯作者：
Irwin MR
影响因子：
10.5
作者：
Denihan, A;Kirby, M;Lawlor, BA
通讯作者：
Lawlor, BA
影响因子：
3.3
作者：
Barefoot, JC;Brummett, BH;Williams, RB
通讯作者：
Williams, RB