Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism.
Dysbiosis, Host Metabolism, and Non-communicable Diseases: Trialogue in the Inborn Errors of Metabolism.
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DOI：
10.3389/fphys.2021.716520
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发表时间：
2021
影响因子：
4
通讯作者：
Verduci E
中科院分区：
文献类型：
--
作者：
Montanari C;Parolisi S;Borghi E;Putignani L;Bassanini G;Zuvadelli J;Bonfanti C;Tummolo A;Dionisi Vici C;Biasucci G;Burlina A;Carbone MT;Verduci E
先天性代谢缺陷是一个复杂的系统模型，需要改变方法，探索介导系统调节的主要因素，内部或外部，克服传统的生化和遗传缺陷的概念。在这方面，在影响代谢通量的既定因素中，即，饮食、生活方式、抗生素、外源性物质、感染因子，以及个体肠道微生物群都应考虑在内。健康的肠道微生物群通过为人类宿主提供独特的代谢功能而有助于维持人类健康。许多患有IEM的患者都采用特殊饮食，这是这些疾病的主要治疗方法。因此，IEM代表了一个很好的模型，以评估特定的饮食模式，在常量营养素组成和营养素质量方面，如何与特定临床表型（“肠表型”）相关的特征性微生物群相关。在本综述中，我们的目的是通过改变的“肠-肝”串扰网络和主要的氧化应激，报告在IEM患者中报告的一种状况，即生态失调与促炎状态之间存在的可能联系，对患者的健康状况产生影响，增加非传染性疾病（NCD）的风险。在此基础上，应更加关注营养状况评估以及可能发生合并症的临床和生化体征，以改善IEM的长期健康状况。平衡的肠道生态系统已被证明对患者健康有积极贡献，其扰动可能会影响IEM患者的临床谱。为此，通过改善膳食产品和混合物的质量，使用益生菌，益生菌和益生菌，可以代表这些复杂疾病的预防和治疗策略。
Inborn errors of metabolism (IEMs) represent a complex system model, in need of a shift of approach exploring the main factors mediating the regulation of the system, internal or external and overcoming the traditional concept of biochemical and genetic defects. In this context, among the established factors influencing the metabolic flux, i.e., diet, lifestyle, antibiotics, xenobiotics, infectious agents, also the individual gut microbiota should be considered. A healthy gut microbiota contributes in maintaining human health by providing unique metabolic functions to the human host. Many patients with IEMs are on special diets, the main treatment for these diseases. Hence, IEMs represent a good model to evaluate how specific dietary patterns, in terms of macronutrients composition and quality of nutrients, can be related to a characteristic microbiota associated with a specific clinical phenotype (“enterophenotype”). In the present review, we aim at reporting the possible links existing between dysbiosis, a condition reported in IEMs patients, and a pro-inflammatory status, through an altered “gut-liver” cross-talk network and a major oxidative stress, with a repercussion on the health status of the patient, increasing the risk of non-communicable diseases (NCDs). On this basis, more attention should be paid to the nutritional status assessment and the clinical and biochemical signs of possible onset of comorbidities, with the goal of improving the long-term wellbeing in IEMs. A balanced intestinal ecosystem has been shown to positively contribute to patient health and its perturbation may influence the clinical spectrum of individuals with IEMs. For this, reaching eubiosis through the improvement of the quality of dietary products and mixtures, the use of pre-, pro- and postbiotics, could represent both a preventive and therapeutic strategy in these complex diseases.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
7.1
作者：
BACH, AC;BABAYAN, VK
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影响因子：
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影响因子：
2.1
作者：
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Schwartz IVD
影响因子：
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通讯作者：
Loomba R