Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.
Association between exercise and the risk of dementia: results from a nationwide longitudinal study in China.
复制标题
运动与痴呆风险之间的关联：中国全国性纵向研究的结果
DOI：
10.1136/bmjopen-2017-017497
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发表时间：
2017-12-04
期刊：
影响因子：
2.9
通讯作者：
Fang Y
中科院分区：
文献类型：
--
作者：
Zhou Z;Fu J;Hong YA;Wang P;Fang Y
本研究旨在探讨中国老年人运动与痴呆风险之间的因果关系。随访持续时间为9年的纵向人群研究。从调查数据库中提取了2002年至2011-2012年中国纵向健康长寿调查波的数据。基线时，共纳入7501例年龄超过65岁的无痴呆受试者。痴呆症被定义为自我报告或代理报告的医生对疾病的诊断。定期锻炼和潜在的混杂变量通过自我报告问卷获得。我们建立了基于时滞广义估计方程的纵向逻辑回归模型，以研究运动与痴呆风险之间的因果关系。在本研究纳入的7501名中国老年人中，在排除失访或死亡者后，有338人在9年的随访期间患上了痴呆症。经常锻炼的人比不经常锻炼的人患痴呆症的几率更低（OR=0.53，95%CI 0.33至0.85）。定期锻炼与痴呆症风险降低有关。决策者应制定有效的公共卫生方案，为公众营造有利于锻炼的环境。
This study was conducted to examine the causal association between exercise and the risk of dementia among older Chinese adults. Longitudinal population-based study with a follow-up duration of 9 years. Data for the Chinese Longitudinal Healthy Longevity Survey waves occurring from 2002 to 2011–2012 were extracted from the survey database. In total, 7501 dementia-free subjects who were older than 65 years were included at baseline. Dementia was defined as a self-reported or proxy-reported physician’s diagnosis of the disease. Regular exercise and potential confounding variables were obtained via a self-report questionnaire. We generated longitudinal logistic regression models based on time-lagged generalised estimating equation to examine the causal association between exercise and dementia risk. Of the 7501 older Chinese people included in this study, 338 developed dementia during the 9-year follow-up period after excluding those who were lost to follow-up or deceased. People who regularly exercised had lower odds of developing dementia (OR=0.53, 95% CI 0.33 to 0.85) than those who did not exercise regularly. Regular exercise was associated with decreased risk of dementia. Policy-makers should develop effective public health programmes and build exercise-friendly environments for the general public.
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影响因子：
14
作者：
Wimo, Anders;Winblad, Bengt;Jonsson, Linus
通讯作者：
Jonsson, Linus
影响因子：
9.9
作者：
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105.7
作者：
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通讯作者：
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DOI：
10.1073/pnas.1015950108
发表时间：
2011-02-15
影响因子：
11.1
作者：
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通讯作者：
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