Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
Meta-analysis identifies six new susceptibility loci for atrial fibrillation.
复制标题
DOI：
10.1038/ng.2261
复制
发表时间：
2012-04-29
期刊：
影响因子：
30.8
通讯作者：
Kaeaeb, Stefan
中科院分区：
文献类型：
--
作者：
Ellinor, Patrick T.;Lunetta, Kathryn L.;Albert, Christine M.;Glazer, Nicole L.;Ritchie, Marylyn D.;Smith, Albert V.;Arking, Dan E.;Mueller-Nurasyid, Martina;Krijthe, Bouwe P.;Lubitz, Steven A.;Bis, Joshua C.;Chung, Mina K.;Doerr, Marcus;Ozaki, Kouichi;Roberts, Jason D.;Smith, J. Gustav;Pfeufer, Arne;Sinner, Moritz F.;Lohman, Kurt;Ding, Jingzhong;Smith, Nicholas L.;Smith, Jonathan D.;Rienstra, Michiel;Rice, Kenneth M.;Van Wagoner, David R.;Magnani, Jared W.;Wakili, Reza;Clauss, Sebastian;Rotter, Jerome I.;Steinbeck, Gerhard;Launer, Lenore J.;Davies, Robert W.;Borkovich, Matthew;Harris, Tamara B.;Lin, Honghuang;Voelker, Uwe;Voelzke, Henry;Milan, David J.;Hofman, Albert;Boerwinkle, Eric;Chen, Lin Y.;Soliman, Elsayed Z.;Voight, Benjamin F.;Li, Guo;Chakravarti, Aravinda;Kubo, Michiaki;Tedrow, Usha B.;Rose, Lynda M.;Ridker, Paul M.;Conen, David;Tsunoda, Tatsuhiko;Furukawa, Tetsushi;Sotoodehnia, Nona;Xu, Siyan;Kamatani, Naoyuki;Levy, Daniel;Nakamura, Yusuke;Parvez, Babar;Mahida, Saagar;Furie, Karen L.;Rosand, Jonathan;Muhammad, Raafia;Psaty, Bruce M.;Meitinger, Thomas;Perz, Siegfried;Wichmann, H-Erich;Witteman, Jacqueline C. M.;Kao, W. H. Linda;Kathiresan, Sekar;Roden, Dan M.;Uitterlinden, Andre G.;Rivadeneira, Fernando;McKnight, Barbara;Sjogren, Marketa;Newman, Anne B.;Liu, Yongmei;Gollob, Michael H.;Melander, Olle;Tanaka, Toshihiro;Stricker, Bruno H. Ch;Felix, Stephan B.;Alonso, Alvaro;Darbar, Dawood;Barnard, John;Chasman, Daniel I.;Heckbert, Susan R.;Benjamin, Emelia J.;Gudnason, Vilmundur;Kaeaeb, Stefan
房颤是一种非常普遍的心律失常，也是中风、心力衰竭和死亡的主要危险因素。我们在欧洲血统的个体中进行了全基因组关联研究（GWAS），包括6，707例房颤患者和52，426例非房颤患者。6个新的房颤易感性位点被确定，并在欧洲血统的个体的额外样本中重复，包括5，381名患有房颤的受试者和10，030名没有房颤的受试者（P < 5 × 10−8）。在欧洲人中发现的4个基因座在日本人的GWAS中进一步复制，包括843名患有房颤的人和3，350名没有房颤的人。所确定的基因座涉及编码与心肺发育、心脏表达的离子通道和细胞信号分子相关的转录因子的候选基因。
Atrial fibrillation is a highly prevalent arrhythmia and a major risk factor for stroke, heart failure and death. We conducted a genome-wide association study (GWAS) in individuals of European ancestry, including 6,707 with and 52,426 without atrial fibrillation. Six new atrial fibrillation susceptibility loci were identified and replicated in an additional sample of individuals of European ancestry, including 5,381 subjects with and 1 0,030 subjects without atrial fibrillation (P < 5 × 10−8). Four of the loci identified in Europeans were further replicated in silico in a GWAS of Japanese individuals, including 843 individuals with and 3,350 individuals without atrial fibrillation. The identified loci implicate candidate genes that encode transcription factors related to cardiopulmonary development, cardiac-expressed ion channels and cell signaling molecules.
登录
查看更多内容
影响因子：
30.8
作者：
Ellinor, Patrick T.;Lunetta, Kathryn L.;Glazer, Nicole L.;Pfeufer, Arne;Alonso, Alvaro;Chung, Mina K.;Sinner, Moritz F.;de Bakker, Paul I. W.;Mueller, Martina;Lubitz, Steven A.;Fox, Ervin;Darbar, Dawood;Smith, Nicholas L.;Smith, Jonathan D.;Schnabel, Renate B.;Soliman, Elsayed Z.;Rice, Kenneth M.;Van Wagoner, David R.;Beckmann, Britt-M;van Noord, Charlotte;Wang, Ke;Ehret, Georg B.;Rotter, Jerome I.;Hazen, Stanley L.;Steinbeck, Gerhard;Smith, Albert V.;Launer, Lenore J.;Harris, Tamara B.;Makino, Seiko;Nelis, Mari;Milan, David J.;Perz, Siegfried;Esko, Tonu;Koettgen, Anna;Moebus, Susanne;Newton-Cheh, Christopher;Li, Man;Moehlenkamp, Stefan;Wang, Thomas J.;Kao, W. H. Linda;Vasan, Ramachandran S.;Noethen, Markus M.;MacRae, Calum A.;Stricker, Bruno H. Ch;Hofman, Albert;Uitterlinden, Andre G.;Levy, Daniel;Boerwinkle, Eric;Metspalu, Andres;Topol, Eric J.;Chakravarti, Aravinda;Gudnason, Vilmundur;Psaty, Bruce M.;Roden, Dan M.;Meitinger, Thomas;Wichmann, H-Erich;Witteman, Jacqueline C. M.;Barnard, John;Arking, Dan E.;Benjamin, Emelia J.;Heckbert, Susan R.;Kaeaeb, Stefan
通讯作者：
Kaeaeb, Stefan
影响因子：
3.5
作者：
de Bakker, Paul I. W.;Ferreira, Manuel A. R.;Voight, Benjamin F.
通讯作者：
Voight, Benjamin F.
影响因子：
158.5
作者：
Brugada, R;Tapscott, T;Roberts, R
通讯作者：
Roberts, R
DOI：
10.1007/pl00008193
发表时间：
2000-01-01
期刊：
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY
影响因子：
--
作者：
Bergwerff, M;Gittenberger-de Groot, AC;Kern, MJ
通讯作者：
Kern, MJ
影响因子：
4
作者：
Beqqali, Abdelaziz;Monshouwer-Kloots, Jantine;Passier, Robert
通讯作者：
Passier, Robert