The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): Comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: A randomize
The Maudsley Outpatient Study of Treatments for Anorexia Nervosa and Related Conditions (MOSAIC): Comparison of the Maudsley Model of Anorexia Nervosa Treatment for Adults (MANTRA) with specialist supportive clinical management (SSCM) in outpatients with broadly defined anorexia nervosa: A randomize
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莫兹利神经性厌食症及相关病症治疗门诊研究 (MOSAIC)：成人神经性厌食症治疗莫兹利模型 (MANTRA) 与专业支持性临床管理 (SSCM) 对广义神经性厌食症门诊患者的比较：随机
DOI：
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发表时间：
2015
影响因子：
5.9
通讯作者：
S. Landau
中科院分区：
文献类型：
--
作者：
U. Schmidt;N. Magill;B. Renwick;Alexandra Keyes;M. Kenyon;H. DeJong;A. Lose;H. Broadbent;R. Loomes;Huma Yasin;C. Watson;S. Ghelani;Eva;L. Serpell;Lorna Richards;E. Johnson;N. Boughton;L. Whitehead;J. Beecham;J. Treasure;S. Landau
客观化
成人神经性厌食症(AN)预后较差，治疗证据有限。这项研究评估了一种新的、有针对性的心理治疗AN(Maudsley Model of Nervosa Treatment for成人；Mantra)与专家支持性临床管理(SSCM)的有效性和可接受性。
方法
142名体重指数(BMI)为18.5公斤/平方米的门诊患者被随机分配到接受20-30次每周治疗(取决于临床严重程度)和附加(4次跟踪治疗，与营养师和照顾者可选的治疗)的Mantra(n=72)或≤(n=70)。随机分组后，分别在基线、6个月和12个月时对治疗情况进行盲法评估。主要结果是12个月时的BMI。次要结果包括进食障碍症状、其他精神病理学、神经认知和社会认知，以及可接受性。还评估了额外的服务利用率。结果采用线性混合模型进行分析。
结果
随着时间的推移，两种治疗方法都显著改善了BMI，并减少了进食障碍症状、痛苦程度和临床损害，但在6个月或12个月时，两组之间没有统计学上的显著差异。随着时间的推移，神经认知和社会认知测量的改善不那么一致。1例SSCM患者死亡。与SSCM相比，在12个月时，Mantra患者对他们的治疗的评价明显更可接受和可信。在额外服务消费方面，不同组之间没有显著差异。
结论
这两种治疗方法似乎都有价值作为广义AN患者的一线门诊干预措施。更长期的结果仍有待评估。
OBJECTIVE
Anorexia nervosa (AN) in adults has poor outcomes, and treatment evidence is limited. This study evaluated the efficacy and acceptability of a novel, targeted psychological therapy for AN (Maudsley Model of Anorexia Nervosa Treatment for Adults; MANTRA) compared with Specialist Supportive Clinical Management (SSCM).
METHOD
One hundred forty-two outpatients with broadly defined AN (body mass index [BMI] ≤ 18.5 kg/m²) were randomly allocated to receive 20 to 30 weekly sessions (depending on clinical severity) plus add-ons (4 follow-up sessions, optional sessions with dietician and with carers) of MANTRA (n = 72) or SSCM (n = 70). Assessments were administered blind to treatment condition at baseline, 6 months, and 12 months after randomization. The primary outcome was BMI at 12 months. Secondary outcomes included eating disorders symptomatology, other psychopathology, neuro-cognitive and social cognition, and acceptability. Additional service utilization was also assessed. Outcomes were analyzed using linear mixed models.
RESULTS
Both treatments resulted in significant improvements in BMI and reductions in eating disorders symptomatology, distress levels, and clinical impairment over time, with no statistically significant difference between groups at either 6 or 12 months. Improvements in neuro-cognitive and social-cognitive measures over time were less consistent. One SSCM patient died. Compared with SSCM, MANTRA patients rated their treatment as significantly more acceptable and credible at 12 months. There was no significant difference between groups in additional service consumption.
CONCLUSIONS
Both treatments appear to have value as first-line outpatient interventions for patients with broadly defined AN. Longer term outcomes remain to be evaluated.
神经性厌食症的情绪接受行为疗法：一项试点研究。
DOI：
10.1002/eat.22241
发表时间：
2014
期刊：
The International journal of eating disorders
影响因子：
--
作者：
Wildes,JenniferE;Marcus,MarshaD;Cheng,Yu;McCabe,ElizabethB;Gaskill,JillA
通讯作者：
Gaskill,JillA
门诊认知矫正疗法是否可以用于神经性厌食症的随机临床试验？
DOI：
10.1002/eat.22134
发表时间：
2013
期刊：
The International journal of eating disorders
影响因子：
--
作者：
Lock,James;Agras,WStewart;Fitzpatrick,KathleenKara;Bryson,SusanW;Jo,Booil;Tchanturia,Kate
通讯作者：
Tchanturia,Kate