The Relationship Between Self-Reported Misophonia Symptoms and Auditory Aversive Generalization Leaning: A Preliminary Report.
The Relationship Between Self-Reported Misophonia Symptoms and Auditory Aversive Generalization Leaning: A Preliminary Report.
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DOI：
10.3389/fnins.2022.899476
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发表时间：
2022
影响因子：
4.3
通讯作者：
Keil, Andreas
中科院分区：
文献类型：
--
作者：
Ward, Richard T.;Gilbert, Faith E.;Pouliot, Jourdan;Chiasson, Payton;McIlvanie, Skylar;Traiser, Caitlin;Riels, Kierstin;Mears, Ryan;Keil, Andreas
恐声症的特点是对特定的“触发”声音产生过度厌恶反应。尽管这种疾病在文献中得到越来越多的认识，但其病因机制和维持因素目前尚不清楚。一些病因学模型提出了巴甫洛夫条件作用的作用，这是一种在类似的恐惧和焦虑相关疾病中进行了大量研究的联想学习过程。此外，习得关联的泛化已被认为是潜在的因果或促成因素。在此框架的基础上，我们假设恐声症症状是过度概括的联想学习的结果，其中对有害事件的厌恶反应也会因对类似事件的反应而发生。或者，正如恐音症联想学习模型所预测的那样，恐音症症状高的参与者可能会表现出条件性威胁和安全线索之间的高度区分。这份初步报告（n = 34）使用自我报告的行为（即价和唤醒评级）和脑电图阿尔法功率降低来检查听觉泛化学习。参与者聆听三种音调不同的正弦音调，其中一种音调（即 CS+）与令人厌恶的大声白噪声爆炸配对，促进令人厌恶的巴甫洛夫泛化学习。通过比较对 CS+ 和其他音调相似的音调的厌恶反应，我们评估了过度概括与强化歧视学习与自我报告的恐音症状相关的程度。在行为上，所有参与者都了解了 CS+ 和有害噪音之间的偶然性，支持恐声症升高的个体对所有刺激都表现出高度的厌恶敏感性，无论条件如何，也与听觉过敏状态无关。在参与者中，顶枕脑电图 α 波段功率降低对 CS+ 音调的反应最为明显，并且这种差异在那些自我报告有恐音症症状的人中更大。目前的初步研究结果并不支持过度概括是恐声症患者自我报告的情感体验特征的观点，但高度的敏感性和辨别学习可能存在于神经层面。
Misophonia is characterized by excessive aversive reactions to specific “trigger” sounds. Although this disorder is increasingly recognized in the literature, its etiological mechanisms and maintaining factors are currently unclear. Several etiological models propose a role of Pavlovian conditioning, an associative learning process heavily researched in similar fear and anxiety-related disorders. In addition, generalization of learned associations has been noted as a potential causal or contributory factor. Building upon this framework, we hypothesized that Misophonia symptoms arise as a consequence of overgeneralized associative learning, in which aversive responses to a noxious event also occur in response to similar events. Alternatively, heightened discrimination between conditioned threat and safety cues may be present in participants high in Misophonia symptoms, as predicted by associative learning models of Misophonia. This preliminary report (n = 34) examines auditory generalization learning using self-reported behavioral (i.e., valence and arousal ratings) and EEG alpha power reduction. Participants listened to three sine tones differing in pitch, with one pitch (i.e., CS+) paired with an aversive loud white noise blast, prompting aversive Pavlovian generalization learning. We assessed the extent to which overgeneralization versus heightened discrimination learning is associated with self-reported Misophonia symptoms, by comparing aversive responses to the CS+ and other tones similar in pitch. Behaviorally, all participants learned the contingencies between CS+ and noxious noise, with individuals endorsing elevated Misophonia showing heightened aversive sensitivity to all stimuli, regardless of conditioning and independent of hyperacusis status. Across participants, parieto-occipital EEG alpha-band power reduction was most pronounced in response to the CS+ tone, and this difference was greater in those with self-reported Misophonia symptoms. The current preliminary findings do not support the notion that overgeneralization is a feature of self-reported emotional experience in Misophonia, but that heightened sensitivity and discrimination learning may be present at the neural level.
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影响因子：
3.7
作者：
Daniels, Emily C.;Rodriguez, Andrew;Zabelina, Darya L.
通讯作者：
Zabelina, Darya L.
影响因子：
3.2
作者：
Friedl, Wendel M.;Keil, Andreas
通讯作者：
Keil, Andreas
DOI：
10.1097/01.chi.0000231974.43966.6e
发表时间：
2006-10-01
影响因子：
13.3
作者：
Ginsburg, Golda S.;Riddle, Mark A.;Davies, Mark
通讯作者：
Davies, Mark
影响因子：
7.7
作者：
Deng, Yuqi;Reinhart, Robert M. G.;Shinn-Cunningham, Barbara G.
通讯作者：
Shinn-Cunningham, Barbara G.
影响因子：
5.7
作者：
Deng, Yuqi;Choi, Inyong;Shinn-Cunningham, Barbara
通讯作者：
Shinn-Cunningham, Barbara