The host response and molecular pathogenesis associated with respiratory syncytial virus infection.
The host response and molecular pathogenesis associated with respiratory syncytial virus infection.
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DOI：
10.2217/fmb.09.1
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发表时间：
2009-04
影响因子：
3.1
通讯作者：
Tripp RA
中科院分区：
文献类型：
--
作者：
Oshansky CM;Zhang W;Moore E;Tripp RA
自从1956年呼吸道合胞病毒(RSV)被分离以来，它作为一种重要的人类病原体在婴儿、老年人和免疫功能低下者中的意义已经确立。许多导致RSV感染、复制和疾病发病的重要机制已经被发现；然而，在这些和相关领域仍然缺乏知识，必须解决这些问题，以促进安全有效的疫苗和治疗方法的开发。为了推进疾病干预策略，需要更好地了解RSV感染的分子发病机制，特别是宿主细胞对RSV感染的反应和转录谱。关于RSV蛋白如何调节分子信号和调节细胞因子和趋化因子对感染的反应，调节细胞程序性死亡的分子信号，以及对感染的先天和获得性免疫反应，正在积累大量的信息。本文就RSV操纵宿主对感染的反应及相关疾病的发病机制作一综述。
Since the isolation of respiratory syncytial virus (RSV) in 1956, its significance as an important human pathogen in infants, the elderly and the immunocompromised has been established. Many important mechanisms contributing to RSV infection, replication and disease pathogenesis have been uncovered; however, there is still insufficient knowledge in these and related areas, which must be addressed to facilitate the development of safe and effective vaccines and therapeutic treatments. A better understanding of the molecular pathogenesis of RSV infection, particularly the host-cell response and transcription profiles to RSV infection, is required to advance disease intervention strategies. Substantial information is accumulating regarding how RSV proteins modulate molecular signaling and regulation of cytokine and chemokine responses to infection, molecular signals regulating programmed cell death, and innate and adaptive immune responses to infection. This review discusses RSV manipulation of the host response to infection and related disease pathogenesis.
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影响因子：
--
作者：
Belz, Gabrielle;Mount, Adele;Masson, Frederick
通讯作者：
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影响因子：
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作者：
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发表时间：
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影响因子：
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作者：
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通讯作者：
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