The X in seX-biased immunity and autoimmune rheumatic disease.
The X in seX-biased immunity and autoimmune rheumatic disease.
复制标题
DOI：
10.1084/jem.20211487
复制
发表时间：
2022-06-06
影响因子：
15.3
通讯作者：
Anguera, Montserrat C. C.
中科院分区：
文献类型：
--
作者：
Jiwrajka, Nikhil;Anguera, Montserrat C. C.
Sex differences in immune function have important implications for autoimmune disease susceptibility and prognosis. This review highlights sex differences in immune health and focuses on the genetic and epigenetic mechanisms contributing to the female bias of autoimmune rheumatic disease. Sexual dimorphism in the composition and function of the human immune system has important clinical implications, as males and females differ in their susceptibility to infectious diseases, cancers, and especially systemic autoimmune rheumatic diseases. Both sex hormones and the X chromosome, which bears a number of immune-related genes, play critical roles in establishing the molecular basis for the observed sex differences in immune function and dysfunction. Here, we review our current understanding of sex differences in immune composition and function in health and disease, with a specific focus on the contribution of the X chromosome to the striking female bias of three autoimmune rheumatic diseases.
登录
查看更多内容
影响因子：
7.4
作者：
Arnold, Arthur P.;Chen, Xuqi
通讯作者：
Chen, Xuqi
影响因子：
17.1
作者：
Clave, Emmanuel;Araujo, Itaua Leston;Toubert, Antoine
通讯作者：
Toubert, Antoine
影响因子：
27.4
作者：
Eloranta, Maija-Leena;Franck-Larsson, Karin;Ronnblom, Lars
通讯作者：
Ronnblom, Lars
DOI：
10.1084/jem.20021553
发表时间：
2003-03-17
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Bennett L;Palucka AK;Arce E;Cantrell V;Borvak J;Banchereau J;Pascual V
通讯作者：
Pascual V
影响因子：
30.8
作者：
Bentham J;Morris DL;Graham DSC;Pinder CL;Tombleson P;Behrens TW;Martín J;Fairfax BP;Knight JC;Chen L;Replogle J;Syvänen AC;Rönnblom L;Graham RR;Wither JE;Rioux JD;Alarcón-Riquelme ME;Vyse TJ
通讯作者：
Vyse TJ