Sickle cell disease and venous thromboembolism: what the anticoagulation expert needs to know.
Sickle cell disease and venous thromboembolism: what the anticoagulation expert needs to know.
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DOI：
10.1007/s11239-013-0895-y
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发表时间：
2013-04
影响因子：
4
通讯作者：
Lanzkron S
中科院分区：
文献类型：
--
作者：
Naik RP;Streiff MB;Lanzkron S
静脉血栓栓塞（VTE）在镰状细胞病（SCD）患者中很常见。SCD患者VTE风险增加的病因是多因素的，既与传统因素有关，也与SCD特异性因素有关。传统的风险因素，如中心静脉导管、频繁住院、缺血性坏死整形外科手术和妊娠，可能导致SCD人群中VTE的发生率增加。此外，SCD本身似乎是一种高凝状态，许多SCD特异性因素，如血栓性缺陷，基因型和脾切除术可能会改变VTE的风险。SCD并发症如急性胸部综合征和肺动脉高压也可能与VTE有关。抗凝专家应了解这些因素，以帮助预防和治疗决策。
Venous thromboembolism (VTE) is common in patients with sickle cell disease (SCD). The etiology of increased risk of VTE in SCD patients is multifactorial and is related to both traditional factors and SCD-specific factors. Traditional risk factors such as central venous catheters, frequent hospitalization, orthopedic surgeries for avascular necrosis, and pregnancy may lead to increased incidence of VTE in the SCD population. In addition, SCD itself appears to be a hypercoagulable state, and many SCD-specific factors such as thrombophilic defects, genotype and splenectomy may modify the risk of VTE. SCD complications such as acute chest syndrome and pulmonary hypertension may also be related to VTE. Anticoagulation experts should be aware of these factors to help inform prophylaxis and treatment decisions.
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影响因子：
5.9
作者：
Adam, Soheir;Jonassaint, Jude;Kruger, Hillary;Kail, Melanie;Orringer, Eugene P.;Eckman, James R.;Ashley-Koch, Allison;Telen, Marilyn J.;De Castro, Laura M.
通讯作者：
De Castro, Laura M.
DOI：
10.1164/rccm.201105-0783oc
发表时间：
2011-11-01
影响因子：
24.7
作者：
Dessap, Armand Mekontso;Deux, Jean-Francois;Maitre, Bernard
通讯作者：
Maitre, Bernard
影响因子：
6.5
作者：
Gardner, Kate;Bell, Cathy;Thein, Swee L.
通讯作者：
Thein, Swee L.
DOI：
10.1161/01.atv.13.3.421
发表时间：
1993-03-01
期刊：
ARTERIOSCLEROSIS AND THROMBOSIS
影响因子：
--
作者：
FOULON, I;BACHIR, D;MACLOUF, J
通讯作者：
MACLOUF, J
影响因子：
3.4
作者：
KENNY, MW;GEORGE, AJ;STUART, J
通讯作者：
STUART, J