The role of neutrophils in thrombosis.
The role of neutrophils in thrombosis.
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DOI：
10.1016/j.thromres.2018.08.005
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发表时间：
2018-10
影响因子：
7.5
通讯作者：
Nayak L
中科院分区：
文献类型：
--
作者：
Kapoor S;Opneja A;Nayak L
尽管有大量证据表明中性粒细胞在血栓形成中起重要作用，但其对血栓形成过程的影响仍存在争议。直到2010年，血小板，凝血因子，纤维蛋白原和单核细胞参与血栓形成过程。过去十年进行的几项研究现在支持越来越多的观点，即中性粒细胞确实对这一过程有重要贡献。中性粒细胞可通过释放中性粒细胞细胞外陷阱（NET）导致病理性静脉和动脉血栓形成或“免疫血栓形成”，NET释放是脓毒症和恶性肿瘤等病理情况下血栓形成的主要原因。此外，血细胞衍生的微粒，包括来自嗜中性粒细胞的微粒，已经涉及血栓形成。最后，中性粒细胞中的炎性小体激活确定了另一个重要机制，该机制可能在嗜中性粒细胞驱动的血栓形成风险中起作用。了解中性粒细胞在血栓形成中的这些作用可能为未来不影响止血的新型抗血栓药物铺平道路。
Despite significant evidence implicating an important role for neutrophils in thrombosis, their impact on the thrombotic process has remained a matter of controversy. Until 2010, platelets, coagulation factors, fibrinogen and monocytes were implicated in the thrombotic process. Several studies conducted over the last decade now support the growing notion that neutrophils indeed do contribute significantly to this process. Neutrophils can contribute to pathologic venous and arterial thrombosis or ‘immunothrombosis’ by the release of neutrophil extracellular traps (NETs) and NET release is emerging as a major contributor to thrombogenesis in pathologic situations such as sepsis and malignancy. Further, blood-cell derived microparticles, including those from neutrophils, have been implicated in thrombus formation. Finally, inflammasome activation in the neutrophil identifies another important mechanism that may be operative in neutrophil-driven risk for thrombosis. The knowledge of these roles of neutrophils in thrombosis may pave the road for novel anti-thrombotic agents in the future that do not affect hemostasis.
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影响因子：
6.7
作者：
Crescente, Marilena;Thomas, Grace M.;Wagner, Denisa D.
通讯作者：
Wagner, Denisa D.
DOI：
10.1161/atvbaha.113.301627
发表时间：
2013-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
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作者：
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通讯作者：
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DOI：
10.1111/j.1538-7836.2011.04544.x
发表时间：
2012-01
期刊：
Journal of thrombosis and haemostasis : JTH
影响因子：
--
作者：
Brill A;Fuchs TA;Savchenko AS;Thomas GM;Martinod K;De Meyer SF;Bhandari AA;Wagner DD
通讯作者：
Wagner DD
影响因子：
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作者：
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通讯作者：
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