Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability.
Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability.
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DOI：
10.1016/j.biopsych.2011.03.039
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发表时间：
2011-10-01
影响因子：
10.6
通讯作者：
Narr, Katherine L.
中科院分区：
文献类型：
--
作者：
Phillips, Owen R.;Nuechterlein, Keith H.;Asarnow, Robert F.;Clark, Kristi A.;Cabeen, Ryan;Yang, Yaling;Woods, Roger P.;Toga, Arthur W.;Narr, Katherine L.
关键词：
结构和弥散张量成像研究暗示精神分裂症患者的灰质和白色物质（WM）异常和神经回路中断。然而，在精神分裂症的结构完整性的表面WM，包括短程协会（U-纤维）和皮质内轴突，还没有被调查。高分辨率的结构和扩散张量图像和复杂的皮质模式匹配方法被用来测量和比较全球和本地的变化，在精神分裂症患者和他们的亲属和社区比较科目和他们的亲属（n = 150）之间的表面WM分数各向异性。与对照受试者相比，患者表现出分布在每个半球的浅表WM分数各向异性降低，特别是在左颞和双侧枕区（所有p <0.05，校正）。此外，通过对精神分裂症患者、患者亲属和对照受试者的生物学风险进行建模，显示分数各向异性根据两个半球以及颞叶和枕叶与患者的相关性而变化（p <0.05，校正）。然而，影响没有生存的校正程序，患者亲属和对照组之间的两组比较。结果扩展了以前的研究结果仅限于深WM通路，以证明皮质连接障碍与精神分裂症，并可能表明遗传易感性的障碍。由于WM的结构完整性在连接灰质区域的网络功能中起着至关重要的作用，因此在神经元交界处的纤维的连贯性和组织性的干扰可能与精神分裂症的特征有关，至少部分归因于疾病相关的遗传因素。
Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of neural circuitry in schizophrenia. However, the structural integrity of the superficial WM, comprising short-range association (U-fibers) and intracortical axons, has not been investigated in schizophrenia. High-resolution structural and diffusion tensor images and sophisticated cortical pattern matching methods were used to measure and compare global and local variations in superficial WM fractional anisotropy between schizophrenia patients and their relatives and community comparison subjects and their relatives (n = 150). Compared with control subjects, patients showed reduced superficial WM fractional anisotropy distributed across each hemisphere, particularly in left temporal and bilateral occipital regions (all p < .05, corrected). Furthermore, by modeling biological risk for schizophrenia in patients, patient relatives, and control subjects, fractional anisotropy was shown to vary in accordance with relatedness to a patient in both hemispheres and in the temporal and occipital lobes (p < .05, corrected). However, effects did not survive correction procedures for two-group comparisons between patient relatives and control subjects. Results extend previous findings restricted to deep WM pathways to demonstrate that disturbances in corticocortical connectivity are associated with schizophrenia and might indicate a genetic predisposition for the disorder. Because the structural integrity of WM plays a crucial role in the functionality of networks linking gray matter regions, disturbances in the coherence and organization of fibers at the juncture of the neuropil might relate to features of schizophrenia at least partially attributable to disease-related genetic factors.
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DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
影响因子：
6.9
作者：
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通讯作者：
Chua, S. E.
DOI：
10.1080/00949659908811936
发表时间：
1999-01-01
影响因子：
1.2
作者：
Anderson, MJ;Legendre, P
通讯作者：
Legendre, P
DOI：
10.1002/ajmg.b.31054
发表时间：
2010-06-05
影响因子：
2.8
作者：
Bertisch, Hilary;Li, Dawei;Hoptman, Matthew J.;DeLisi, Lynn E.
通讯作者：
DeLisi, Lynn E.
影响因子：
17.7
作者：
Butler, Pamela D.;Hoptman, Matthew J.;Lim, Kelvin O.
通讯作者：
Lim, Kelvin O.