The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update.
The Utility of Nicotinamide N-Methyltransferase as a Potential Biomarker to Predict the Oncological Outcomes for Urological Cancers: An Update.
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烟酰胺N-甲基转移酶是预测泌尿外科癌症的肿瘤学结局的潜在生物标志物：更新。
DOI：
10.3390/biom11081214
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发表时间：
2021-08-16
期刊：
影响因子：
5.5
通讯作者：
Emanuelli M
中科院分区：
文献类型：
--
作者：
Campagna R;Pozzi V;Spinelli G;Sartini D;Milanese G;Galosi AB;Emanuelli M
烟酰胺n -甲基转移酶（NNMT）以s -腺苷- l-蛋氨酸为甲基供体，催化烟酰胺n -甲基化反应。酶过表达已被描述在许多非肿瘤性疾病，以及在广泛的实体恶性肿瘤。本综述旨在报告和讨论科学文献中有关NNMT表达及其在主要泌尿系统肿瘤（即肾癌、膀胱癌和前列腺癌）中的潜在作用的证据。引用的研究数据清楚地表明NNMT上调（病理组织与正常组织）与上述肿瘤有关。除此之外，酶水平也被发现与关键预后参数和患者生存相关。有趣的是，NNMT过表达也出现在外周体液中，如血液和尿液，从而导致候选酶作为早期和非侵入性检测这些癌症的有希望的生物标志物。研究结果无疑表明，NNMT具有促进细胞增殖、迁移和侵袭的能力，并可能参与癌症进展、转移和对化疗和放疗的耐药性等基本事件。鉴于这些证据，我们有理由认为NNMT作为泌尿系统肿瘤诊断和预后的潜在生物标志物以及有效抗癌治疗的分子靶点具有广阔的应用前景。
Nicotinamide N-methyltransferase (NNMT) catalyzes the N-methylation reaction of nicotinamide, using S-adenosyl-L-methionine as the methyl donor. Enzyme overexpression has been described in many non-neoplastic diseases, as well as in a wide range of solid malignancies. This review aims to report and discuss evidence available in scientific literature, dealing with NNMT expression and the potential involvement in main urologic neoplasms, namely, renal, bladder and prostate cancers. Data illustrated in the cited studies clearly demonstrated NNMT upregulation (pathological vs. normal tissue) in association with these aforementioned tumors. In addition to this, enzyme levels were also found to correlate with key prognostic parameters and patient survival. Interestingly, NNMT overexpression also emerged in peripheral body fluids, such as blood and urine, thus leading to candidate the enzyme as promising biomarker for the early and non-invasive detection of these cancers. Examined results undoubtedly showed NNMT as having the capacity to promote cell proliferation, migration and invasiveness, as well as its potential participation in fundamental events highlighting cancer progression, metastasis and resistance to chemo- and radiotherapy. In the light of this evidence, it is reasonable to attribute to NNMT a promising role as a potential biomarker for the diagnosis and prognosis of urologic neoplasms, as well as a molecular target for effective anti-cancer treatment.
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DOI：
10.1016/j.omtn.2018.03.011
发表时间：
2018-06-01
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Bach DH;Kim D;Bae SY;Kim WK;Hong JY;Lee HJ;Rajasekaran N;Kwon S;Fan Y;Luu TT;Shin YK;Lee J;Lee SK
通讯作者：
Lee SK
影响因子：
7.3
作者：
Chen, Dongxing;Li, Linjie;Huang, Rong
通讯作者：
Huang, Rong
影响因子：
4.3
作者：
Campagna, Roberto;Salvolini, Eleonora;Emanuelli, Monica
通讯作者：
Emanuelli, Monica
影响因子：
4.2
作者：
Hah, Young-Sool;Cho, Hee Young;Yoon, Tae-Jin
通讯作者：
Yoon, Tae-Jin
影响因子：
4.6
作者：
Cui, Yanyan;Yang, Dawei;Guan, Fangxia
通讯作者：
Guan, Fangxia