[(18)F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.
[(18)F]mFBG PET-CT for detection and localisation of neuroblastoma: a prospective pilot study.
复制标题
DOI：
10.1007/s00259-022-06063-6
复制
发表时间：
2023-03
影响因子：
9.1
通讯作者：
de Keizer, Bart
中科院分区：
文献类型：
--
作者：
Samim, Atia;Blom, Thomas;Poot, Alex J. J.;Windhorst, Albert D. D.;Fiocco, Marta;Tolboom, Nelleke;Braat, Arthur J. A. T.;Viol, Sebastiaan L. Meyer;van Rooij, Rob;van Noesel, Max M. M.;Lam, Marnix G. E. H.;Tytgat, Godelieve A. M.;de Keizer, Bart
Meta-[18F]氟苯基胍([18F]mFBG)是一种正电子发射断层扫描(PET)放射性示踪剂，允许对表达去甲肾上腺素转运体的肿瘤进行快速和高分辨率成像。这项初步研究探讨了[18F]mFBG PET-CT用于神经母细胞瘤成像的可行性。在一项前瞻性的单中心研究中，我们招募了神经母细胞瘤儿童，进行了Meta-[123I]碘苯基胍([123I]MIBG)扫描，包括全身平面闪烁成像和单光子发射计算机断层扫描(SPECT-CT)。在[123I]MIBG扫描后2周内，分别于注射[18F]mFBG(2mBq/kg)后1h和2h进行全身PET-CT扫描。对扫描对上检测到的肿瘤位置进行比较。软组织疾病通过皮损数量进行量化，骨骼疾病通过SIOPEN评分进行量化。14例患者(中位年龄4.9岁，n = 4期13例，n = 1例4S期)进行了2 0次[12 3I]mIBG和[18F]mFBG扫描。[18F]mFBG注射耐受性良好，所有患者均未发生相关不良事件。[18F]mFBGPET-CT的平均扫描时间(9.0min，SD1.9)明显短于[123I]MIBG扫描的平均扫描时间(84.5min，SD10.5)，p <； 0.01。大多数肿瘤的定位是在注射[18F]mFBG PET-CT后1小时和2小时检测到的。与[123I]MIBG扫描相比，[18F]mFBG PET-CT分别在40%、55%和5%的扫描对中发现了更多、相同和更低数量的软组织病变，在55%、30%和15%的扫描对中分别发现了更高、相同和更低的SIOPEN评分。平均而言，与[123I]MIBG扫描相比，在[18F]mFBG PET-CT上，每个患者多发现两个软组织病变，SIOPEN评分高6分。本研究的结果证明了[18F]mFBG PET-CT用于神经母细胞瘤成像的可行性。与[123I]MIBG扫描相比，[18F]mFBG PET-CT可发现更多的神经母细胞瘤。[18F]mFBG PET-CT可用于神经母细胞瘤的未来分期和疗效评估。荷兰试验寄存器NL8152。网上版载有补充材料，可在10.1007/s00259-022-06063-6查阅。
Meta-[18F]fluorobenzylguanidine ([18F]mFBG) is a positron emission tomography (PET) radiotracer that allows for fast and high-resolution imaging of tumours expressing the norepinephrine transporter. This pilot study investigates the feasibility of [18F]mFBG PET-CT for imaging in neuroblastoma. In a prospective, single-centre study, we recruited children with neuroblastoma, referred for meta-[123I]iodobenzylguanidine ([123I]mIBG) scanning, consisting of total body planar scintigraphy in combination with single-photon emission computed tomography-CT (SPECT-CT). Within two weeks of [123I]mIBG scanning, total body PET-CTs were performed at 1 h and 2 h after injection of [18F]mFBG (2 MBq/kg). Detected tumour localisations on scan pairs were compared. Soft tissue disease was quantified by number of lesions and skeletal disease by SIOPEN score. Twenty paired [123I]mIBG and [18F]mFBG scans were performed in 14 patients (median age 4.9 years, n = 13 stage 4 disease and n = 1 stage 4S). [18F]mFBG injection was well tolerated and no related adverse events occurred in any of the patients. Mean scan time for [18F]mFBG PET-CT (9.0 min, SD 1.9) was significantly shorter than for [123I]mIBG scanning (84.5 min, SD 10.5), p < 0.01. Most tumour localisations were detected on the 1 h versus 2 h post-injection [18F]mFBG PET-CT. Compared to [123I]mIBG scanning, [18F]mFBG PET-CT detected a higher, equal, and lower number of soft tissue lesions in 40%, 55%, and 5% of scan pairs, respectively, and a higher, equal, and lower SIOPEN score in 55%, 30%, and 15% of scan pairs, respectively. On average, two more soft tissue lesions and a 6-point higher SIOPEN score were detected per patient on [18F]mFBG PET-CT compared to [123I]mIBG scanning. Results of this study demonstrate feasibility of [18F]mFBG PET-CT for neuroblastoma imaging. More neuroblastoma localisations were detected on [18F]mFBG PET-CT compared to [123I]mIBG scanning. [18F]mFBG PET-CT shows promise for future staging and response assessment in neuroblastoma. Dutch Trial Register NL8152. The online version contains supplementary material available at 10.1007/s00259-022-06063-6.
登录
查看更多内容
影响因子：
8.4
作者：
Rotstein BH;Wang L;Liu RY;Patteson J;Kwan EE;Vasdev N;Liang SH
通讯作者：
Liang SH
影响因子：
10.6
作者：
Fukuoka, Makoto;Taki, Junichi;Kinuya, Seigo
通讯作者：
Kinuya, Seigo
影响因子：
45.3
作者：
BRODEUR, GM;PRITCHARD, J;VOUTE, PA
通讯作者：
VOUTE, PA
复发高危神经母细胞瘤患者的治疗和疗效： 德国试验结果
影响因子：
3.2
作者：
Simon, Thorsten;Berthold, Frank;Hero, Barbara
通讯作者：
Hero, Barbara
影响因子：
9.3
作者：
Aboian, Mariam S.;Huang, Shih-ying;Seo, Youngho
通讯作者：
Seo, Youngho