Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement.
Untangling COVID-19 and autoimmunity: Identification of plausible targets suggests multi organ involvement.
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解开COVID-19和自身免疫：确定可能的靶点表明涉及多器官。
DOI：
10.1016/j.molimm.2021.06.021
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发表时间：
2021-09
影响因子：
3.6
通讯作者：
Janakiraman V
中科院分区：
文献类型：
--
作者：
Mohkhedkar M;Venigalla SSK;Janakiraman V
COVID-19多器官表现和炎症加重的潜在机制尚不清楚。SARS-CoV-2引发自身免疫的假设正在引起人们的关注，在本研究中，我们已经确定了28种人类蛋白，其中含有与SARS-CoV-2肽同源的区域，这些区域可能在表现出自身免疫性疾病的COVID-19患者中充当自身抗原。有趣的是，这些保守区域位于经实验验证的SARS-CoV-2蛋白的B细胞表位中。报告的人类蛋白质在典型的自身免疫性疾病中显示存在针对它们的自身抗体，这可能解释了SARS-CoV-2感染后自身免疫性疾病的频繁发生。此外，所提出的自身抗原广泛的组织分布表明它们通过分子模仿参与多器官表现。我们认为，我们的报告可能有助于指导后续必要的抗原特异性研究，其结果将对COVID-19肺外症状的管理具有长期相关性。
Underlying mechanisms of multi-organ manifestations and exacerbated inflammation in COVID-19 are yet to be delineated. The hypothesis of SARS-CoV-2 triggering autoimmunity is gaining attention and, in the present study, we have identified 28 human proteins harbouring regions homologous to SARS-CoV-2 peptides that could possibly be acting as autoantigens in COVID-19 patients displaying autoimmune conditions. Interestingly, these conserved regions are amongst the experimentally validated B cell epitopes of SARS-CoV-2 proteins. The reported human proteins have demonstrated presence of autoantibodies against them in typical autoimmune conditions which may explain the frequent occurrence of autoimmune conditions following SARS-CoV-2 infection. Moreover, the proposed autoantigens’ widespread tissue distribution is suggestive of their involvement in multi-organ manifestations via molecular mimicry. We opine that our report may aid in directing subsequent necessary antigen-specific studies, results of which would be of long-term relevance in management of extrapulmonary symptoms of COVID-19.
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影响因子：
4.6
作者：
Arcanjo A;Logullo J;Menezes CCB;de Souza Carvalho Giangiarulo TC;Dos Reis MC;de Castro GMM;da Silva Fontes Y;Todeschini AR;Freire-de-Lima L;Decoté-Ricardo D;Ferreira-Pereira A;Freire-de-Lima CG;Barroso SPC;Takiya C;Conceição-Silva F;Savino W;Morrot A
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64.5
作者：
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通讯作者：
Bogunovic, Dusan
影响因子：
15.3
作者：
FOEDINGER, D;ANHALT, GJ;RAPPERSBERGER, K
通讯作者：
RAPPERSBERGER, K
影响因子：
4.7
作者：
Feng, Zijian;Li, Qun;McGoogan, Jennifer M.
通讯作者：
McGoogan, Jennifer M.