Urinary specific gravity measures in the U.S. population: Implications for the adjustment of non-persistent chemical urinary biomarker data.
Urinary specific gravity measures in the U.S. population: Implications for the adjustment of non-persistent chemical urinary biomarker data.
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DOI：
10.1016/j.envint.2021.106656
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发表时间：
2021-11
影响因子：
11.8
通讯作者：
Buckley JP
中科院分区：
文献类型：
--
作者：
Kuiper JR;O'Brien KM;Ferguson KK;Buckley JP
尿液生物标志物通常使用肌酐进行样本稀释校正，这受到社会人口因素和某些健康状况的影响。目前尚不清楚这些因素是否同样影响比重。确定比重和肌酐的预测因子，并比较使用这些措施校正样本稀释的估计化学浓度的方法。我们评估了NHANES 2007-2008年参与者（n = 7257）中尿比重和肌酐的预测因素。我们使用两种方法校正了邻苯二甲酸单正丁酯（MnBP）的稀释浓度，每种方法均适用于比重和肌酸酐：使用稀释指示剂的样本平均值进行校正（即，比重或肌酸酐）和协变量调整的标准化。我们比较了分布，并使用Bland-Altman图目视评估了未校正或校正浓度的一致性，并通过Kendall τa进行了统计学评估。我们按年龄类别对所有分析进行分层（即，6-19或20岁以上）。性别、人种/种族、体重指数和身高与尿比重和肌酐相关。两种方法和稀释指示剂的校正MnBP浓度的分布相当，但方法之间的协议是更大的比重。此外，当使用协变量调整的标准化方法校正时，比重和肌酐校正的MnBP浓度彼此之间的一致性略高。像肌酸酐一样，比重与社会人口统计学和身体成分变量相关。将这些因素作为稀释校正方法的一部分，对于最大限度地减少偏倚可能很重要。
Urinary biomarkers are often corrected for sample dilution using creatinine, which is influenced by sociodemographic factors and certain health conditions. It is unknown whether these factors similarly influence specific gravity. To identify predictors of specific gravity and creatinine and compare methods for correcting estimated chemical concentrations for sample dilution using these measures. We assessed predictors of urinary specific gravity and creatinine among NHANES 2007-2008 participants (n = 7257). We corrected concentrations of mono-n-butyl phthalate (MnBP) for dilution using two methods, each applied to both specific gravity and creatinine: correction using a sample mean of the dilution indicator (i.e., specific gravity or creatinine) and covariate-adjusted standardization. We compared distributions and assessed the agreement of uncorrected or corrected concentrations visually using Bland-Altman plots and statistically by Kendall’s τa. We stratified all analyses by age category (i.e., 6–19 or 20+ years of age). Gender, race/ethnicity, body mass index, and height were associated with urinary specific gravity and creatinine. Distributions of corrected MnBP concentrations were comparable for both methods and dilution indicators, but agreement between methods was greater for specific gravity. Additionally, specific gravity- and creatinine-corrected MnBP concentrations had slightly greater agreement with each other when corrected using a covariate-adjusted standardization method. Specific gravity, like creatinine, is associated with sociodemographic and body composition variables. Accounting for these factors as part of the dilution correction method may be important to minimize bias.
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影响因子：
10.4
作者：
O'Brien KM;Upson K;Cook NR;Weinberg CR
通讯作者：
Weinberg CR
影响因子：
7.9
作者：
O'Brien KM;Upson K;Buckley JP
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Buckley JP
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作者：
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作者：
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通讯作者：
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7
作者：
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通讯作者：
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