High seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya.
High seroprevalence of SARS-CoV-2 but low infection fatality ratio eight months after introduction in Nairobi, Kenya.
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DOI：
10.1016/j.ijid.2021.08.062
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Osoro E
中科院分区：
文献类型：
--
作者：
Ngere I;Dawa J;Hunsperger E;Otieno N;Masika M;Amoth P;Makayotto L;Nasimiyu C;Gunn BM;Nyawanda B;Oluga O;Ngunu C;Mirieri H;Gachohi J;Marwanga D;Munywoki PK;Odhiambo D;Alando MD;Breiman RF;Anzala O;Njenga MK;Bulterys M;Herman-Roloff A;Osoro E
非洲新冠肺炎的发病率和死亡率低于预期是多种因素造成的，其中包括监测不力。这项研究估计了肯尼亚内罗毕SARS-CoV-2疫情流行八个月后感染SARS-CoV-2的负担。2020年11月，采用多阶段随机抽样的方法，在内罗毕范围内进行了以人口为基础的横断面调查。对同意的家庭成员的血清进行了SARS-CoV-2抗体检测。在调整了人群结构和测试性能后，评估了血清阳性率。感染死亡率(IFRS)是通过将研究估计数与报告病例和死亡人数进行比较来计算的。在1164名个体中，调整后的血清阳性率为34.7%(95%可信区间为31.8-37.6)。一半的登记家庭至少有一名积极的参与者。在人口密度较高的地区，血清阳性率升高(Spearman‘s r=0.63；p=0.009)。20-59岁的人的血清阳性率至少是0-9岁的人的两倍。国际财务报告准则是每100,000名感染者中有40人，60岁的人≥的国际财务报告准则更高。截至2020年11月，超过三分之一的内罗毕居民接触到了SARS-CoV-2，这表明疫情的广泛传播。然而，IFR比欧洲和美国的报告低10倍，支持撒哈拉以南非洲地区被认为较低的发病率和死亡率。
The lower than expected COVID-19 morbidity and mortality in Africa has been attributed to multiple factors, including weak surveillance. This study estimated the burden of SARS-CoV-2 infections eight months into the epidemic in Nairobi, Kenya. A population-based, cross-sectional survey was conducted using multi-stage random sampling to select households within Nairobi in November 2020. Sera from consenting household members were tested for antibodies to SARS-CoV-2. Seroprevalence was estimated after adjusting for population structure and test performance. Infection fatality ratios (IFRs) were calculated by comparing study estimates with reported cases and deaths. Among 1,164 individuals, the adjusted seroprevalence was 34.7% (95% CI 31.8-37.6). Half of the enrolled households had at least one positive participant. Seropositivity increased in more densely populated areas (spearman's r=0.63; p=0.009). Individuals aged 20-59 years had at least two-fold higher seropositivity than those aged 0-9 years. The IFR was 40 per 100,000 infections, with individuals ≥60 years old having higher IFRs. Over one-third of Nairobi residents had been exposed to SARS-CoV-2 by November 2020, indicating extensive transmission. However, the IFR was >10-fold lower than that reported in Europe and the USA, supporting the perceived lower morbidity and mortality in sub-Saharan Africa.
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DOI：
10.4269/ajtmh.20-0816
发表时间：
2020-11
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Kempen JH;Abashawl A;Suga HK;Nigussie Difabachew M;Kempen CJ;Tesfaye Debele M;Menkir AA;Assefa MT;Asfaw EH;Habtegabriel LB;Sitotaw Addisie Y;Nilles EJ;Longenecker JC
通讯作者：
Longenecker JC
DOI：
10.1016/j.jcv.2020.104710
发表时间：
2021-01
期刊：
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
影响因子：
--
作者：
Abdelmoniem R;Fouad R;Shawky S;Amer K;Elnagdy T;Hassan WA;Ali AM;Ezzelarab M;Gaber Y;Badary HA;Musa S;Talaat H;Kassem AM;Tantawi O
通讯作者：
Tantawi O
影响因子：
4.5
作者：
Gibbons, Cheryl L.;Mangen, Marie-Josee J.;Kretzschmar, Mirjam E. E.
通讯作者：
Kretzschmar, Mirjam E. E.
影响因子：
3.7
作者：
Halatoko WA;Konu YR;Gbeasor-Komlanvi FA;Sadio AJ;Tchankoni MK;Komlanvi KS;Salou M;Dorkenoo AM;Maman I;Agbobli A;Wateba MI;Adjoh KS;Goeh-Akue E;Kao YB;Kpeto I;Pana P;Kinde-Sossou R;Tamekloe A;Nayo-Apétsianyi J;Assane SH;Prine-David M;Awoussi SM;Djibril M;Mijiyawa M;Dagnra AC;Ekouevi DK
通讯作者：
Ekouevi DK
影响因子：
16.6
作者：
GeurtsvanKessel, Corine H.;Okba, Nisreen M. A.;Koopmans, Marion
通讯作者：
Koopmans, Marion